ArticleFrontiers in aging neuroscience2020
Attention and Functional Connectivity Among Patients With Early-Stage Subcortical Ischemic Vascular Disease and Alzheimer's Disease.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Functional brain changes in vascular cognitive impairment: a whole brain ALE meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- An ALE Meta-Analysis of Specific Functional MRI Studies on Subcortical Vascular Cognitive Impairment.Frontiers in neurology · 2021Pooled it
- Dual Transcranial Direct Current Stimulation Modulates Hierarchical Functional Network Organization in Post-Stroke Cognitive Impairment: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- [Effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Vascular endothelial growth factor (VEGF)-related blood flow regulation and anti-inflammation in the protection of Danzhu Fuyuan Granules against cognitive impairment.Metabolic brain disease · 2026Article
- Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia.Frontiers in aging neuroscience · 2025Review
- Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger's disease with mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Retired night shift workers exhibit poorer neurocognitive function compared to retired day workers.Sleep · 2023Article
- Review
- Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence.Frontiers in aging neuroscience · 2023Review
- Altered intrinsic brain activity in patients with CSF1R-related leukoencephalopathy.Brain imaging and behavior · 2022Article
- Altered insular functional connectivity correlates to impaired vigilant attention after sleep deprivation: A resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- The protective impact of education on brain structure and function in Alzheimer's disease.BMC neurology · 2021Article
- Cognitive Deficits Associated With Dysphagia in Patients With Dementia.Journal of neurogastroenterology and motility · 2021Article
- Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study.Scientific reports · 2021Article
- Dissociable Functional Brain Networks Associated With Apathy in Subcortical Ischemic Vascular Disease and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease.Frontiers in aging neuroscience · 2021Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study compared attention profiles and functional connectivity of frontal regions in patients with early-stage subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD). Twenty patients with SIVD, 32 patients with AD, and 23 subjects with normal cognition (NC) received cognition and resting-state functional MRI (rs-fMRI) evaluations. The Cognitive Abilities Screening Instrument (CASI) was used to assess global cognition, and simple attention, processing speed, divided attention, and vigilance/sustained attention were evaluated using the Digit Span Forward, Trail Making Test, Symbol Digit Modality Test, and Conners Continuous Performance Test, respectively. Voxel-based regional homogeneity (ReHo) derived from rs-fMRI data was analyzed to identify significant clusters, which were further correlated with attention profiles. Although the patients with SIVD and AD had comparable global cognitive ability, those with SIVD exhibited worse divided attention and vigilance/sustained attention than those with AD. Compared with the NC group, the patients with SIVD exhibited decreased ReHo within the right middle frontal gyrus (MFG) and left anterior cingulate gyrus (ACG), whereas the patients with AD exhibited increased ReHo within the right orbital part of frontal regions. Correlations between these three clusters with attention exhibited distinct patterns according to the dementia subtype, as did attention indices with significance in predicting global cognition. In summary, our study suggested that worse attention performance was associated with functional disconnection within the frontal regions among patients with SIVD than in those with AD. Frontal functional disconnection may underlie the pathogenesis responsible for defective divided attention, vigilance/sustained attention, and notable within-group variations identified in SIVD.
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