Evidence map›Paper›PMID 32903841›Full record

SynthesisFrontiers in public health2020

D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis.

Panagiotis Paliogiannis, Arduino Aleksander Mangoni, Paola Dettori, Gheyath K Nasrallah, Gianfranco Pintus, Angelo Zinellu

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. SPECT/CT Scan Images to Evaluate COVID-19 Pulmonary Complications: A Systematic Review.International journal of environmental research and public health · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Panagiotis PaliogiannisDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Arduino Aleksander MangoniDepartment of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Paola DettoriCure and Health Center, Sassari, Italy.
Gheyath K NasrallahDepartment of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.
Gianfranco PintusDepartment of Medical Laboratory Sciences, College of Health Sciences, and Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Angelo ZinelluBiomedical Sciences, University of Sassari, Sassari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures. The activation of the coagulation cascade is a common feature of disseminated intravascular coagulation and adverse clinical outcomes in COVID-19 patients. In this study, we conducted a meta-analysis aiming to investigate differences in serum D-dimer concentrations in patients with and without severe COVID-19 disease. An electronic search in Medline (PubMed), Scopus and Web of Science was performed with no language restrictions, and 13 articles were reporting on 1,807 patients (585, 32.4% with severe disease) were finally identified and included in the meta-analysis. The pooled results of all studies revealed that the D-dimer concentrations were significantly higher in patients with more severe COVID-19 (SMD: 0.91 mg/L; 95% CI, 0.75 to 1.07 mg/L,

Indexed as

COVID-19Communicable Disease ControlFibrin Fibrinogen Degradation ProductsHumansSARS-CoV-2Fibrin Fibrinogen Degradation Productsfibrin fragment DcoagulationCOVID-19D-dimerSARS-CoV-2thrombosis

Identifiers

PMID32903841
PMCPMC7438945

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.