ArticleFrontiers in aging neuroscience2020
Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The APOE4-estrogen-microglia axis in perimenopausal cognitive changes: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease.Biology of sex differences · 2025Article
- Leveraging research into sex differences and steroid hormones to improve brain health.Nature reviews. Endocrinology · 2025Review
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Estradiol improves behavior in FAD transgenic mice that expressFrontiers in endocrinology · 2024Article
- Steroid hormones: risk and resilience in women's Alzheimer disease.Frontiers in aging neuroscience · 2023Review
- 17β-estradiol ameliorates delirium-like phenotypes in a murine model of urinary tract infection.Scientific reports · 2022Article
- [Testosterone and Alzheimer's disease].Problemy endokrinologii · 2022Article
- Impact of Testosterone on Alzheimer's Disease.The world journal of men's health · 2022Review
- Ovariectomy-induced hormone deprivation aggravates AβFrontiers in endocrinology · 2022Article
- Estrogen Deficiency Induces Mitochondrial Damage Prior to Emergence of Cognitive Deficits in a Postmenopausal Mouse Model.Frontiers in aging neuroscience · 2021Article
- The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins.International journal of molecular sciences · 2020Article
- Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
It has been suggested that there is a critical window for estrogen replacement therapy (ERT) in postmenopausal women with Alzheimer's disease (AD); however, supporting evidence is lacking. To address this issue, we investigated the effective period for estradiol (E2) treatment using a mouse model of AD. Four-month-old female APPswe/PSEN1dE9 (APP/PS1) mice were ovariectomized (OVX) and treated with E2 for 2 months starting at the age of 4 months (early period), 6 months (mid-period), or 8 months (late period). We then evaluated hippocampal neurogenesis, β-amyloid (Aβ) accumulation, telomerase activity, and hippocampal-dependent behavior. Compared to age-matched wild type mice, APP/PS1 mice with intact ovaries showed increased proliferation of hippocampal neural stem cells (NSCs) at 8 months of age and decreased proliferation of NSCs at 10 months of age; meanwhile, Aβ accumulation progressively increased with age, paralleling the reduced survival of immature neurons. OVX-induced depletion of E2 in APP/PS1 mice resulted in elevated Aβ levels accompanied by elevated p75 neurotrophin receptor (p75
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