ReviewFrontiers in cellular and infection microbiology2020
Orthohantavirus Pathogenesis and Cell Tropism.
Review in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Bleeding in haemorrhagic fever with renal syndrome: A systematic review characterising the loss of haemostasis in hantavirus infections.PLoS neglected tropical diseases · 2026Pooled it
- Temporal trends in critical care burden and outcomes of Andes virus-associated hantavirus cardiopulmonary syndrome: a national Chilean cohort.Intensive care medicine · 2026Article
- Hantavirus on the rise: clinical, virological, immunological, and public health perspectives.Current opinion in immunology · 2026Review
- Omics Approaches in Hantavirus Research: Current Advances, Challenges, and Future Perspectives.Biotech (Basel (Switzerland)) · 2026Review
- Maintenance of Hokkaido virus, a genotype ofJournal of virology · 2026Article
- Orthohantavirus Infection Mimicking Acute Viral Hepatitis: An Underrecognized Clinical Presentation.Pathogens (Basel, Switzerland) · 2026Review
- Andes virus and the aging host: lessons from the 2026 outbreak and a framework for age-related disease severity.GeroScience · 2026Review
- Hantavirus Disease: A Comprehensive Narrative Review of Epidemiology, Pathogenesis, Diagnosis, and Treatment.Cureus · 2026Review
- Serological cross-reactivity and identification of an acute Seoul orthohantavirus case in a dengue outbreak from Vietnam.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026Article
- Divergent prognostic roles and risk determinants of myocardial injury in SFTS and HFRS.Tropical medicine and health · 2026Article
- Virome diversity and zoonotic risks of rodents along ecological gradients in the Northern Tianshan Mountains, China.Microbiome · 2026Article
- t-PA/PAI-1 complex expression correlates with the severity in hantaan virus-induced hemorrhagic fever with renal syndrome.Frontiers in cellular and infection microbiology · 2026Article
- First Molecular Detection of Orthohantaviruses (Pathogens (Basel, Switzerland) · 2025Article
- Virus Genome Sequences in the Blood of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients.medRxiv : the preprint server for health sciences · 2025Article
- Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates.PLoS pathogens · 2025Article
- Interactions Between Hantavirus Nucleoprotein and Glycoproteins: A Quantitative Fluorescence Microscopy Study.Viruses · 2025Article
- Urinalysis of a Hantaan virus-infected mouse model of hemorrhagic fever with renal syndrome.The Journal of veterinary medical science · 2025Article
- Review
- Achievement and Challenges in Orthohantavirus Vaccines.Vaccines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthohantaviruses are zoonotic viruses that are naturally maintained by persistent infection in specific reservoir species. Although these viruses mainly circulate among rodents worldwide, spill-over infection to humans occurs. Orthohantavirus infection in humans can result in two distinct clinical outcomes: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). While both syndromes develop following respiratory transmission and are associated with multi-organ failure and high mortality rates, little is known about the mechanisms that result in these distinct clinical outcomes. Therefore, it is important to identify which cell types and tissues play a role in the differential development of pathogenesis in humans. Here, we review current knowledge on cell tropism and its role in pathogenesis during orthohantavirus infection in humans and reservoir rodents. Orthohantaviruses predominantly infect microvascular endothelial cells (ECs) of a variety of organs (lungs, heart, kidney, liver, and spleen) in humans. However, in this review we demonstrate that other cell types (e.g., macrophages, dendritic cells, and tubular epithelium) are infected as well and may play a role in the early steps in pathogenesis. A key driver for pathogenesis is increased vascular permeability, which can be direct effect of viral infection in ECs or result of an imbalanced immune response in an attempt to clear the virus. Future studies should focus on the role of identifying how infection of organ-specific endothelial cells as well as other cell types contribute to pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.