Evidence map›Paper›PMID 32903667›Full record

ArticleFrontiers in pharmacology2020

Inhibition of the Glycine Receptor alpha 3 Function by Colchicine.

Carola Muñoz-Montesino, Carlos F Burgos, Cesar O Lara, Camila R Riquelme, David Flaig, Victoria P San Martin, Luis G Aguayo, Jorge Fuentealba, Patricio A Castro, Leonardo Guzmán and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Carola Muñoz-MontesinoDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Carlos F BurgosDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Cesar O LaraDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Camila R RiquelmeDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
David FlaigDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Victoria P San MartinDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Luis G AguayoDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Jorge FuentealbaDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Patricio A CastroDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Leonardo GuzmánDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Gonzalo E YévenesDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Gustavo Moraga-CidDepartamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
University of Concepción · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colchicine is a plant alkaloid that is widely used as a therapeutic agent. It is widely accepted that colchicine reduces the production of inflammatory mediators mainly by altering cytoskeleton dynamics due to its microtubule polymerization inhibitory activity. However, other lines of evidence have shown that colchicine exerts direct actions on the function of ion channels, which are independent of cytoskeleton alterations. Colchicine is able to modify the function of several pentameric ligand-gated ion channels, including glycine receptors (GlyRs). Previous electrophysiological studies have shown that colchicine act as an antagonist of GlyRs composed by the

Indexed as

antagonistcolchicineglycine receptorpainpentameric ligand-gated ion channel

Identifiers

PMID32903667
PMCPMC7438739
OpenAlexW3046671650

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.