Evidence map›Paper›PMID 32903666›Full record

ReviewFrontiers in physiology2020

Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging.

Rosaly Correa-de-Araujo, Odessa Addison, Iva Miljkovic, Bret H Goodpaster, Bryan C Bergman, Richard V Clark, Joanne W Elena, Karyn A Esser, Luigi Ferrucci, Michael O Harris-Love and 5 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07255001 (Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma), which is not on this map. Cited by 295 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
295citing papers in PubMed, 5 pooled it
24.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07255001 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma: Potential for Better Understanding of Treatment Trajectory and Survival

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2025 to 2027Enrolled50ConditionsPancreatic Ductal Adenocarcinoma (PDAC), Hand Grip StrengthArmsHand grip strength assessments using a dynamometer
3 · Its place in the literature

Who cites it

295 citing papers in PubMed, 5 syntheses or guidelines pooled it, 415 citations in OpenAlex.

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235 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 1 country.

Rosaly Correa-de-AraujoDivision of Geriatrics and Clinical Gerontology, National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, United States.
Odessa AddisonDepartment of Veterans Affairs and Veterans Affairs Medical Center Baltimore, Geriatric Research, Education and Clinical Center (GRECC), Baltimore, MD, United States.
Iva MiljkovicDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
Bret H GoodpasterAdventHealth Translational Research Institute, Orlando, FL, United States.
Bryan C BergmanDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Richard V ClarkUnited States Anti-Doping Agency, Colorado Springs, CO, United States.
Joanne W ElenaNational Cancer Institute, National Institutes of Health, U.S Department of Health and Human Services, Bethesda, MD, United States.
Karyn A EsserDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States.
Luigi FerrucciIntramural Research Program, National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, United States.
Michael O Harris-LovePhysical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Steve B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention Wake Forest School of Medicine, Winston-Salem, NC, United States.
Amanda LorbergsCanadian Frailty Network, Kingston, ON, Canada.
John A ShepherdDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States.
Gerald I ShulmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.
Clifford J RosenThe Maine Medical Center Research Institute, Scarborough, ME, United States.
National Institute on Aging · USGeriatric Research Education and Clinical Center · USMaine Medical Center Research Institute · USNational Institutes of Health · USTranslational Research Institute for Metabolism and Diabetes · USUnited States Anti-Doping Agency · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Florida · USUniversity of Hawaii System · USUniversity of Maryland, Baltimore · USUniversity of Pittsburgh · USWake Forest University · USYale University · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Development of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human PrimatesR01DK119968 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2019 to 2024
$2.7M
Glucagon Regulation of Hepatic Mitochondrial Activity and Glucose Metabolism by InsP3R-1R01DK116774 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2018 to 2021
$1.7M
Detection and Treatment of Sarcopenia and Myosteatosis in Older African AmericansIK2RX001854 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI HARRIS-LOVE, MICHAEL · 2015 to 2020
–
NIA NIH HHS P30 AG028740NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK116774NIDDK NIH HHS R01 DK119968RRD VA IK2 RX001854
6 · The paper itself

Abstract

Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An interdisciplinary workshop convened by the National Institute on Aging Division of Geriatrics and Clinical Gerontology on September 2018, discussed myosteatosis in the context of skeletal muscle function deficit (SMFD). Its purpose was to gain a better understanding of the roles of myosteatosis in aging muscles and metabolic disease, particularly its potential determinants and clinical consequences, and ways of properly assessing it. Special attention was given to functional status and standardization of measures of body composition (including the value of D

Indexed as

agingintermuscular adipose tissueintramuscular adipose tissueintramyocellular lipidsmobility-disabilitymuscle qualitymyosteatosisskeletal muscle function deficit

Identifiers

PMID32903666
PMCPMC7438777
OpenAlexW3048054064

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.