Evidence map›Paper›PMID 32903627›Full record

ArticleFrontiers in behavioral neuroscience2020

Neonatal Tactile Stimulation Alters Behaviors in Heterozygous Serotonin Transporter Male Rats: Role of the Amygdala.

Karine Roversi, Carolina Buizza, Paola Brivio, Francesca Calabrese, Michel M M Verheij, Caren T D Antoniazzi, Marilise E Burger, Marco A Riva, Judith R Homberg

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Karine RoversiDepartment of Physiology and Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Carolina BuizzaDepartment of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy.
Paola BrivioDepartment of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy.
Francesca CalabreseDepartment of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy.
Michel M M VerheijDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.
Caren T D AntoniazziInternational Centre for Neurotherapeutics, Dublin City University, Dublin, Ireland.
Marilise E BurgerDepartment of Physiology and Pharmacology, Health Sciences Center, Federal University of Santa Maria, Santa Maria, Brazil.
Marco A RivaDepartment of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, Italy.
Judith R HombergDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.
University of Milan · ITRadboud University Medical Center · NLUniversidade Federal de Santa Maria · BRDublin City University · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serotonin transporter (SERT) gene, especially the short allele of the human serotonin transporter linked polymorphic region (5-HTTLPR), has been associated with the development of stress-related neuropsychiatric disorders. In line, exposure to early life stress in SERT knockout animals contributes to anxiety- and depression-like behavior. However, there is a lack of investigation of how early-life exposure to beneficial stimuli, such as tactile stimulation (TS), affects later life behavior in these animals. In this study, we investigated the effect of TS on social, anxiety, and anhedonic behavior in heterozygous SERT knockouts rats and wild-type controls and its impact on gene expression in the basolateral amygdala. Heterozygous SERT

Indexed as

amygdalaanxietyBdnfneonatal periodserotonin transporter knockouttactile stimulation

Identifiers

PMID32903627
PMCPMC7438747
OpenAlexW3048871838

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.