ArticleFrontiers in chemistry2020
Fluorescence Resonant Energy Transfer-Based Quantum Dot Sensor for the Detection of Calcium Ions.
Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Modulation of DNA Nanostructure Morphology by Metal Ions and Temperature: An AFM Study.Nanomaterials (Basel, Switzerland) · 2026Article
- Aptamers as emerging tools for plant disease management: From biosensing to active modulation.iScience · 2025Review
- Innovations in ion-selective optodes: a comprehensive exploration of modern designs and nanomaterial integration.Frontiers in bioengineering and biotechnology · 2024Review
- Simple fluorescence chemosensor for the detection of calcium ions in water samples and its application in bio-imaging of cancer cells.RSC advances · 2022Article
- Optoelectronic Neural Interfaces Based on Quantum Dots.ACS applied materials & interfaces · 2022Review
- Manganese-based nanoadjuvants for enhancement of immune effect of DNA vaccines.Frontiers in bioengineering and biotechnology · 2022Article
- Optimizing Calcium Detection Methods in Animal Systems: A Sandbox for Synthetic Biology.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A simple optical aptasensor has been synthesized for the detection of calcium ions. This sensing approach employs a semiconductor quantum dot (QD)-gold nanoparticle as the donor-quencher pair and operates on the principle of fluorescence resonant energy transfer (FRET). On binding with calcium ions, the DNA aptamer undergoes a conformational change, which changes the distance between the quantum dot and the gold nanoparticle, conjugated on the 5' terminal and 3' terminal of the aptamer, respectively. This phenomenon results in the quenching of the quantum dot emission. In this sensor, a maximum quenching of 22.42 ± 0.71% has been achieved at 35 nM calcium ion concentration while the limit of detection has been determined to be 3.77 pM. The sensor has been found to have high specificity for calcium ions in comparison to other metal ions like sodium, magnesium, and potassium. The molecular apta-beacons also demonstrated successful endocytosis and FRET-based calcium ion detection in osteocyte cells when conjugated with a cell-penetrating peptide (DSS).
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