ArticleFrontiers in aging neuroscience2020
The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- African ancestry GWAS of dementia in a large military cohort identifies significant risk loci.Molecular psychiatry · 2023Pooled it
- Linking eye movements, pupil responses, and brain networks in early cognitive decline.Alzheimer's research & therapy · 2026Article
- Article
- Advanced Brain Age Prediction Using Multi-Head Self-Attention: A Comparative Analysis of Western and Middle Eastern MRI Datasets.Research square · 2025Article
- Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition.Ageing research reviews · 2024Review
- Construction and validation of a brain magnetic resonance imaging template for normal older Koreans.BMC neurology · 2024Article
- Longitudinal association between muscle and bone loss: Results of US and Japanese cohort studies.Journal of cachexia, sarcopenia and muscle · 2024Article
- Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity.Alzheimer's research & therapy · 2023Article
- Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- Diagnostic Blood Biomarkers in Alzheimer's Disease.Biomedicines · 2022Article
- Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain.Communications medicine · 2022Article
- Association Between Socioeconomic Status and In Utero Fetal Brain Development.JAMA network open · 2021Article
- Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each OtherFrontiers in aging neuroscience · 2021Article
- Deep Learning-Based Segmentation to Establish East Asian Normative Volumes Using Multisite Structural MRI.Diagnostics (Basel, Switzerland) · 2020Article
- Preliminary assessment of age- and sex-related differences in brain volume using Quantib™ brain quantification: a study in a Vietnamese cohort.Frontiers in neurologyArticle
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The aging of the brain is a well-investigated topic, but existing analyses have mainly focused on Caucasian samples. To investigate brain aging in East Asians, we measured cortical and subcortical volumes from magnetic resonance imaging (MRI) scans of 1,008 cognitively normal elderly Koreans from the Gwangju Alzheimer's and Related Dementia cohort and 342 Caucasians from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. To determine whether the aging effect varies with ethnicity and sex, beta coefficients of age and confidence intervals (CIs) were estimated in each ethnicity-sex group using a bootstrap method and a regression analysis using the relative volume to intracranial volume as predicted. The betas or aging slopes largely were not significantly different between ethnicity and sex groups in most types of brain structures. However, ethnic differences between the two female groups were found in the brain, most cortical regions, and a few subcortical regions. Ethnic differences in brain aging are likely due in large part to genetic factors; thus, we compared carriers and non-carriers of a gene relevant to longevity and neurodegenerative diseases, such as
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.