ArticlePloS one2020
Impact of a pre-feeding oral stimulation program on first feed attempt in preterm infants: Double-blind controlled clinical trial.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of the Oral Stimulation Program in Extreme Preterm Infants: A Randomized Clinical Trial
Maternal Role in Sensory-motor Stimulation for Oral Feed Establishment in Preterm Neonates: MSMS Trial
Effect of Oropharyngeal Colostrum Administration On Early Feeding Skills in Premature Infants
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Effect of tactile-kinesthetic stimulation on breastfeeding performance among preterm neonates in a neonatal intensive care unit.Maternal health, neonatology and perinatology · 2026Article
- Effectiveness of Preterm Infant Oral Motor Intervention (PIOMI) on oral feeding readiness among preterm infants: a quasi-experimental study.BMC pediatrics · 2026Article
- Effect of oromotor stimulation on early sucking behavior and later development in preterm newborns.Bioinformation · 2025Article
- The effectiveness of oral motor interventions on the weight gain, independent oral feeding, and length of hospital stay in hospitalized preterm infants: A systematic review and meta-analysis.Health science reports · 2024Article
- A swallowing and breastfeeding intervention programme for small and sick neonates embedded in kangaroo mother care.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2024Article
- Oral stimulation for promoting oral feeding in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Effectiveness of multistimulation approach on feeding habits of low-birth-weight babies-A randomized control trial.European journal of obstetrics & gynecology and reproductive biology: X · 2022Article
- Oral feeding skills in premature infants: A concept analysis.Belitung nursing journal · 2022Article
- Influence of Full Oral Feeding Acquisition on Growth of Premature Infants.Frontiers in pediatrics · 2022Article
- To: First Brazilian recommendation on physiotherapy with sensory motor stimulation in newborns and infants in the intensive care unit.Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of an oral stimulation program in preterm on the performance in the first oral feeding, oral feeding skills and transition time from tube to total oral intake. STUDY DESIGNER: Double-blind randomized clinical trial including very preterm newborns. Congenital malformations, intracranial hemorrhage grade III or IV, bronchopulmonary dysplasia, and necrotizing enterocolitis were excluded. Intervention group (GI) received an oral stimulation program of tactile extra-, peri-, and intraoral tactile manipulation once a day for 15 minutes, during a 10-day period. Control group (GII) received sham procedure with same duration of time. Feeding ability was assessed by a speech-language pathologist blinded to group assignment. The classification of infants' oral performance was determined by Oral Feeding Skills (OFS). Neonates were monitored until hospital discharge.
resultsSeventy-four (37 in each group) were randomized. Mean gestational ages and birth weights were 30±1.4 and 30±1.5 weeks, and 1,452±330g and 1,457±353g for intervention and control groups, respectively. Infants in the intervention group had significantly better rates than infants in the control group on: mean proficiency (PRO) (41.5%±18.3 vs. 19.9%±11.6 (p<0.001)), transfer rate (RT) (2.3 mL/min and 1.1 mL/min (p<0.001)) and overall transfer (OT) (57.2%±19.7 and 35.0%±15.7 (p<0.001)). Median transition time from tube to oral feeding was 4 (3-11) and 8 (7-13) days in intervention and control groups, respectively (p = 0.003). Intake of breast milk was found to reduce transition time from tube feeds to exclusive oral feeding (p<0.001, HR 1.01, 95%CI 1.005-1.019), but the impact of the study intervention remained significant (p = 0.007, HR 1.97, 95%CI 1.2-3.2).
conclusionInfants who were breast-fed and an oral stimulation program proved beneficial in reducing transition time from tube feeding to oral feeding.
trial registrationClinicalTrials.gov number NCT03025815.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.