Evidence map›Paper›PMID 32902809›Full record

ArticleEndocrine2021

Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population.

Mariana Bonjiorno Martins, Fernando de Assis Batista, Natassia Elena Bufalo, Karina Colombera Peres, Murilo Meneghetti, Ligia Vera Montali da Assumpção, Laura Sterian Ward

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In one paragraph

Article in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mariana Bonjiorno Martins *Laboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St., Campinas, SP, Brazil. mbonjiorno@gmail.com.ORCID http://orcid.org/0000-0002-9659-6528
Fernando de Assis Batista *Laboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St., Campinas, SP, Brazil.
Natassia Elena BufaloLaboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St., Campinas, SP, Brazil.
Karina Colombera PeresLaboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St., Campinas, SP, Brazil.
Murilo MeneghettiLaboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St., Campinas, SP, Brazil.
Ligia Vera Montali da AssumpçãoDivision of Endocrinology, Department of Medicine, Faculty of Medical Sciences-University of Campinas (Unicamp), 251, Vital Brazil St., Campinas, SP, Brazil.
Laura Sterian WardLaboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessália Vieira de Camargo St., Campinas, SP, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/16830-0
6 · The paper itself

Abstract

backgroundIL-4 is known to present abnormal expression in thyroid tumors and SNPs in the IL-4 and its receptor IL-4R genes are associated to risk and mortality of various types of cancer.

methodsIn order to evaluate their role in differentiated thyroid cancer (DTC), we investigated genetic frequencies of two IL-4 promoter SNPs (rs2070874 C>T, rs2243250 C>T) and four non-synonymous SNPs of the IL-4R gene (rs1805010 A>G, rs1805012 C>T, rs1805013 C>T, rs1801275 A>G) in 300 DTC patients matched to 300 controls. All patients were managed according to current guidelines and followed-up for a period of 12-252 months (69.20 ± 52.70 months).

resultsAlthough none of the six investigated SNPs showed association with risk of DTC, rs1805010 was associated with age of diagnosis and the SNPs rs1805012 and rs1801275 were associated to gender. Further, in-silico analysis showed that all these three SNPs were able to cause decreased stability of the protein. We were not able to demonstrate any other association to clinical features of aggressiveness or to patients' prognosis.

conclusionsThese findings indicate that although genetic variants in IL-4 and IL-4R do not influence the risk or outcome of DTC patients, their influence on the behavior of thyroid tumors deserves further investigation.

Indexed as

Interleukin-4Receptors, Interleukin-4Thyroid NeoplasmsBrazilCase-Control StudiesDemographyGenetic Predisposition to DiseaseGenotypeHumansInterleukin-4 Receptor alpha SubunitPolymorphism, Single NucleotideIL4 protein, humanIL4R protein, humanInterleukin-4Interleukin-4 Receptor alpha SubunitReceptors, Interleukin-4Cancer susceptibilityInterleukinsSNPs polymorphismsThyroid cancer

Identifiers

PMID32902809
OpenAlexW3086028409

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.