Trial reportTranslational stroke research2021
Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial.
Trial report in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07338383 (An Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager for Detection of Intracranial Hemorrhage in the Acute Care Setting), which is not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager for Detection of Intracranial Hemorrhage in the Acute Care Setting
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Effect of tranexamic acid for acute spontaneous intracerebral haemorrhage: a systematic review and individual patient data meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2026Pooled it
- Tranexamic acid in the management of traumatic brain injury: a systematic review and meta-analysis with trial sequential analysis.Einstein (Sao Paulo, Brazil) · 2025Pooled it
- Predictors of early neurological deterioration in patients with intracerebral hemorrhage: a systematic review and meta-analysis.Journal of neurology · 2024Pooled it
- Haemostatic therapies for stroke due to acute, spontaneous intracerebral haemorrhage.The Cochrane database of systematic reviews · 2023Pooled it
- Effects of subarachnoid extension following intracerebral hemorrhage: A systematic review and meta-analysis.Medicine · 2022Pooled it
- Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score.Journal of the American Heart Association · 2022Trial
- Location-Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH.Annals of clinical and translational neurology · 2026Article
- Non-HDL/HDL Cholesterol Ratio as a Protective Factor for Functional Recovery Following Intracerebral Hemorrhage: A Prospective Cohort Study.International journal of general medicine · 2026Article
- Prehospital intensive blood pressure management in intracerebral hemorrhage: current evidence, controversies, and future directions.Frontiers in medicine · 2026Review
- Practicability of Activating Transcription Factor 3 as a Serological Marker for Severity Appraisal and Outcome Anticipation in Acute Supratentorial Intracerebral Hemorrhage: A Two-center Observational Analytical Study.Brain and behavior · 2025Observational
- Stress hyperglycemia indexes and early neurological deterioration in spontaneous intracerebral hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Clinical, radiological, and radiomics feature-based explainable machine learning models for prediction of neurological deterioration and 90-day outcomes in mild intracerebral hemorrhage.BMC medical imaging · 2025Article
- Golden hour management in the patient with intraparenchymal cerebral hemorrhage: an Italian intersociety document.Journal of anesthesia, analgesia and critical care · 2025Review
- Thiamine administration and in-hospital mortality in patients with traumatic brain injury: analysis of the MIMIC-IV database.Frontiers in neurology · 2025Article
- Predictors and Outcomes of Hematoma Expansion and Neurological Decline in Intracerebral Hemorrhage: A Multisite Mobile Stroke Unit Study.Stroke (Hoboken, N.J.) · 2025Article
- Added Value of Frequency of Imaging Markers for Prediction of Outcome After Intracerebral Hemorrhage: A Secondary Analysis of Existing Data.Neurocritical care · 2024Article
- How much of the variance in functional outcome related to intracerebral hemorrhage volume is already apparent in neurological status at admission?Journal of neurology · 2024Article
- Time-Dependent Changes in Hematoma Expansion Rate after Supratentorial Intracerebral Hemorrhage and Its Relationship with Neurological Deterioration and Functional Outcome.Diagnostics (Basel, Switzerland) · 2024Article
- Predicting functional outcomes of patients with spontaneous intracerebral hemorrhage based on explainable machine learning models: a multicenter retrospective study.Frontiers in neurology · 2024Article
- Tranexamic acid: a narrative review of its current role in perioperative medicine and acute medical bleeding.Frontiers in medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 6 countries.
Funding
Abstract
Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexamic acid in IntraCerebral Hemorrhage-2 (TICH-2) randomized controlled trial were analyzed. Neurological deterioration was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) of ≥ 4 or a decline in Glasgow Coma Scale of ≥ 2. Neurological deterioration was considered to be early if it started ≤ 48 h and late if commenced between 48 h and 7 days after onset. Logistic regression was used to identify predictors and effects of neurological deterioration and the effect of tranexamic acid on neurological deterioration. Of 2325 patients, 735 (31.7%) had neurological deterioration: 590 (80.3%) occurred early and 145 (19.7%) late. Predictors of early neurological deterioration included recruitment from the UK, previous ICH, higher admission systolic blood pressure, higher NIHSS, shorter onset-to-CT time, larger baseline hematoma, intraventricular hemorrhage, subarachnoid extension and antiplatelet therapy. Older age, male sex, higher NIHSS, previous ICH and larger baseline hematoma predicted late neurological deterioration. Neurological deterioration was independently associated with a modified Rankin Scale of > 3 (aOR 4.98, 3.70-6.70; p < 0.001). Tranexamic acid reduced the risk of early (aOR 0.79, 0.63-0.99; p = 0.041) but not late neurological deterioration (aOR 0.76, 0.52-1.11; p = 0.15). Larger hematoma size, intraventricular and subarachnoid extension increased the risk of neurological deterioration. Neurological deterioration increased the risk of death and dependency at day 90. Tranexamic acid reduced the risk of early neurological deterioration and warrants further investigation in ICH. URL: https://www.isrctn.com Unique identifier: ISRCTN93732214.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.