Evidence map›Paper›PMID 32902676›Full record

Trial reportArchives of gynecology and obstetrics2021

Effect of ejaculatory abstinence period on sperm DNA fragmentation and pregnancy outcome of intrauterine insemination cycles:  A prospective randomized study.

Cihan Kabukçu, Nazlı Çil, Ümit Çabuş, Erkan Alataş

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04361292 (Effect of Ejaculatory Abstinence Period on Sperm DNA Fragmentation and Pregnancy Outcome of Intrauterine Insemination Cycles), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04361292 nacompletednot on this map

Effect of Ejaculatory Abstinence Period on Sperm DNA Fragmentation and Pregnancy Outcome of Intrauterine Insemination Cycles: A Prospective Randomized Study

TypeinterventionalSponsorPamukkale UniversityRan2019 to 2020Enrolled120ConditionsInfertility, Spermatozoa, Reproductive DisorderArmsINTRAUTERINE INSEMINATION
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Sperm DNA Fragmentation and Fertility.Advances in experimental medicine and biology · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cihan KabukçuDepartment of Obstetrics and Gynecology, School of Medicine, Pamukkale University, 20070, Denizli, Turkey. cihankabukcu@yahoo.com.ORCID 0000-0003-3331-5714
Nazlı ÇilDepartment of Histology and Embryology, School of Medicine, Pamukkale University, Denizli, Turkey.
Ümit ÇabuşDepartment of Obstetrics and Gynecology, School of Medicine, Pamukkale University, 20070, Denizli, Turkey.
Erkan AlataşDepartment of Obstetrics and Gynecology, School of Medicine, Pamukkale University, 20070, Denizli, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of the ejaculatory abstinence period on sperm DNA fragmentation and pregnancy rates in IUI cycles.

methodsOne hundred and twenty couples with unexplained infertility were prospectively randomized into two groups on the second day of their cycle. In group A, patients had 1-day ejaculatory abstinence period; in group B patients had 3-day ejaculatory abstinence period. Each patient was stimulated with gonadotropins, and IUI was performed. The primary outcome measure was clinical pregnancy and sperm DNA fragmentation rate.

resultsThe pregnancy rate was 17.3% and 18.5% in group A and group B, respectively. No significant difference was found among the groups (p = 0.803). The sperm DNA fragmentation rate for group A (20.71 ± 11.01) and group B (23.78 ± 12.64) were almost similar (p = 0.187). The sperm DNA fragmentation rate was 24.89 ± 12.89 in pregnant couples and 21.71 ± 11.69 in non-pregnant couples (p = 0.288).

conclusionEven after a short abstinence period of 1 day, compared to the standard abstinence period of 3 days, pregnancy rates are similar among unexplained infertility couples undergoing ovarian stimulation and IUI. CLINICALTRIALS: The study was registered at ClinicalTrials.gov with ID NCT04361292. Date of registration: 27 April 2020. The study was registered retrospectively.

Indexed as

DNA FragmentationPregnancy OutcomePregnancy RateAdultDNAEjaculationFemaleFertilization in VitroGonadotropinsHumansInfertilityInsemination, ArtificialMaleOvulation InductionPregnancyProspective StudiesDNAGonadotropinsEjaculatory abstinenceIntrauterine inseminationSemen analysisSperm DNA fragmentationTUNEL assay

Identifiers

PMID32902676

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.