ArticleeLife2020
Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability.Molecular neurobiology · 2026Review
- The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer's disease.Archives of toxicology · 2025Review
- An AlphaFold guided model for the evolution of the CaMKII interactome.bioRxiv : the preprint server for biology · 2025Article
- The treatment of myocardial ischemia-reperfusion injury: potential roles of natural drug modulating CaMKII.Frontiers in pharmacology · 2025Review
- Structural basis for the concerted antiphage activity in the SIR2-HerA system.Nucleic acids research · 2024Article
- Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity.Protein science : a publication of the Protein Society · 2024Article
- Hub stability in the calcium calmodulin-dependent protein kinase II.Communications biology · 2024Article
- Studying CaMKII: Tools and standards.Cell reports · 2024Review
- Biomolecular dynamics in the 21st century.Biochimica et biophysica acta. General subjects · 2024Review
- Methods optimization for the expression and purification of human calcium calmodulin-dependent protein kinase II alpha.PloS one · 2024Article
- Oligomeric organization of membrane proteins from native membranes at nanoscale spatial and single-molecule resolution.Nature nanotechnology · 2024Article
- Controlling the interaction between CaMKII and Calmodulin with a photocrosslinking unnatural amino acid.Protein science : a publication of the Protein Society · 2023Article
- Synaptic memory and CaMKII.Physiological reviews · 2023Review
- Article
- The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Review
- CaMKIIα as a Promising Drug Target for Ischemic Grey Matter.Brain sciences · 2022Review
- Calcium signaling in neurodevelopment and pathophysiology of autism spectrum disorders.Molecular biology reports · 2022Review
- Synaptic memory survives molecular turnover.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep.PLoS biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Deepti Karandur *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-6949-6337
Moitrayee Bhattacharyya *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-2168-1541
Zijie Xia *Department of Chemistry, University of California, Berkeley, Berkeley, United States.
Young Kwang LeeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0003-0056-6357
Serena MuratciogluDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Darren McAffeeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Ethan D McSpaddenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Baiyu QiuDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Jay T GrovesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Evan R WilliamsCalifornia Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.
John KuriyanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-4414-5477
QB3 · USUniversity of California, Berkeley · US
Funding
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0MUncovering the molecular mechanism of learning and memory with an emphasis on Down SyndromeR00GM126145 · NIGMS · YALE UNIVERSITY · PI BHATTACHARYYA, MOITRAYEE · 2020 to 2022
$747kMolecular mechanism for the regulation of activation in calcium/calmodulin-dependent protein kinase II (CaMKII)K99GM126145 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BHATTACHARYYA, MOITRAYEE · 2017 to 2018
$180kHoward Hughes Medical InstituteNational Science Foundation CHE-1609866NIGMS NIH HHS K99 GM126145NIGMS NIH HHS R01 GM116961
Abstract
Ca
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 2Escherichia coliHEK293 CellsHoloenzymesHumansMolecular Dynamics SimulationPhosphorylationProteinsSignal TransductionCalcium-Calmodulin-Dependent Protein Kinase Type 2CAMK2N1 protein, humanHoloenzymesProteinsactivation-dependent disassemblybiochemistryCaMKIIchemical biologymolecular dynamics simulationnative mass spectrometryspread of activation state
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.