ArticleeLife2020
Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
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- The cost of efficiency in flexible neural representations.bioRxiv : the preprint server for biology · 2026Article
- Neural geometry in the human hippocampus enables generalization across spatial position and gaze.ArXiv · 2026Article
- Inferring latent behavioral strategy from the representational geometry of prefrontal cortex activity.Nature communications · 2026Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Article
- Interactively Integrating Reach and Grasp Information in Macaque Premotor Cortex.Neuroscience bulletin · 2025Article
- Working Memory Updating in the Macaque Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Practice reshapes the geometry and dynamics of task-tailored representations.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- Control Principles of Neural Dynamics Revealed by the Neurobiology of Timing.Annual review of neuroscience · 2025Review
- Task structure tailors the geometry of neural representations in human lateral prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Dynamic tracking of objects in the macaque dorsomedial frontal cortex.Nature communications · 2025Article
- A transient high-dimensional geometry affords stable conjunctive subspaces for efficient action selection.Nature communications · 2024Article
- Rational inattention in neural coding for economic choice.bioRxiv : the preprint server for biology · 2024Article
- Practice Reshapes the Geometry and Dynamics of Task-tailored Representations.bioRxiv : the preprint server for biology · 2024Article
- A computational mechanism of cue-stimulus integration for pain in the brain.Science advances · 2024Article
- A Transient High-dimensional Geometry Affords Stable Conjunctive Subspaces for Efficient Action Selection.bioRxiv : the preprint server for biology · 2024Article
- Prefrontal neuronal dynamics in the absence of task execution.Nature communications · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The lateral prefrontal cortex is involved in the integration of multiple types of information, including working memory and motor preparation. However, it is not known how downstream regions can extract one type of information without interference from the others present in the network. Here, we show that the lateral prefrontal cortex of non-human primates contains two minimally dependent low-dimensional subspaces: one that encodes working memory information, and another that encodes motor preparation information. These subspaces capture all the information about the target in the delay periods, and the information in both subspaces is reduced in error trials. A single population of neurons with mixed selectivity forms both subspaces, but the information is kept largely independent from each other. A bump attractor model with divisive normalization replicates the properties of the neural data. These results provide new insights into neural processing in prefrontal regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.