ArticleJournal of neurophysiology2020
Amplitude modulation transfer functions reveal opposing populations within both the inferior colliculus and medial geniculate body.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Formant-frequency encoding in the inferior colliculus of awake rabbit: Physiological and model responses.Hearing research · 2026Article
- Timbre Encoding in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Modeling auditory enhancement: Efferent control of cochlear gain can explain level dependence and effects of hearing loss.The Journal of the Acoustical Society of America · 2026Article
- GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.The Journal of physiology · 2025Article
- Chirp sensitivity and vowel coding in the inferior colliculus.Hearing research · 2025Article
- Mechanisms of Tone-in-Noise Encoding in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Precise spike-timing information in the brainstem is well aligned with the needs of communication and the perception of environmental sounds.PLoS biology · 2025Article
- Forward masking in the inferior colliculus: Dynamics of discharge-rate recovery after narrowband noise maskers.The Journal of the Acoustical Society of America · 2025Article
- Modelling neural coding in the auditory midbrain with high resolution and accuracy.Nature machine intelligence · 2025Article
- Profile analysis in listeners with normal and elevated audiometric thresholds: Behavioral and modeling results.The Journal of the Acoustical Society of America · 2024Article
- A computational model of auditory chirp-velocity sensitivity and amplitude-modulation tuning in inferior colliculus neurons.Journal of computational neuroscience · 2024Article
- A Subcortical Model for Auditory Forward Masking with Efferent Control of Cochlear Gain.eNeuro · 2024Article
- Limitations in human auditory spectral analysis at high frequencies.The Journal of the Acoustical Society of America · 2024Article
- A Computational Model of Auditory Chirp-Velocity Sensitivity and Amplitude-Modulation Tuning in Inferior Colliculus Neurons.Research square · 2024Article
- GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.bioRxiv : the preprint server for biology · 2024Article
- Neural Fluctuation Contrast as a Code for Complex Sounds: The Role and Control of Peripheral Nonlinearities.Hearing research · 2024Review
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- Head-related transfer functions of rabbits within the front horizontal plane.Hearing research · 2024Article
- Sensitivity to direction and velocity of fast frequency chirps in the inferior colliculus of awake rabbit.Hearing research · 2023Article
- Subcortical auditory model including efferent dynamic gain control with inputs from cochlear nucleus and inferior colliculus.The Journal of the Acoustical Society of America · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Based on single-unit recordings of modulation transfer functions (MTFs) in the inferior colliculus (IC) and the medial geniculate body (MGB) of the unanesthetized rabbit, we identified two opposing populations: band-enhanced (BE) and band-suppressed (BS) neurons. In response to amplitude-modulated (AM) sounds, firing rates of BE and BS neurons were enhanced and suppressed, respectively, relative to their responses to an unmodulated noise with a one-octave bandwidth. We also identified a third population, designated hybrid neurons, whose firing rates were enhanced by some modulation frequencies and suppressed by others. Our finding suggests that perception of AM may be based on the co-occurrence of enhancement and suppression of responses of the opposing populations of neurons. Because AM carries an important part of the content of speech, progress in understanding auditory processing of AM sounds should lead to progress in understanding speech perception. Each of the BE, BS, and hybrid types of MTFs comprised approximately one-third of the total sample. Modulation envelopes having short duty cycles of 20-50% and raised-sine envelopes accentuated the degree of enhancement and suppression and sharpened tuning of the MTFs. With sinusoidal envelopes, peak modulation frequencies were centered around 32-64 Hz among IC BE neurons, whereas the MGB peak frequencies skewed toward lower frequencies, with a median of 16 Hz. We also tested an auditory-brainstem model and found that a simple circuit containing fast excitatory synapses and slow inhibitory synapses was able to reproduce salient features of the BE- and BS-type MTFs of IC neurons.
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