ArticleJournal of cognitive neuroscience2020
Network Localization of Executive Function Deficits in Patients with Focal Thalamic Lesions.
Article in Journal of cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Network Mechanisms of Cognitive Control
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Dissociable Thalamocortical Circuit Disruptions During Contextual Fear Renewal in PTSD.medRxiv : the preprint server for health sciences · 2026Article
- A clinical neuroimaging platform for rapid, automated lesion detection and personalized post-stroke outcome prediction.NPJ digital medicine · 2026Article
- Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons.Experimental physiology · 2026Article
- Two structural alteration patterns of the thalamus in patients with schizophrenia.BMC medicine · 2025Article
- The neural basis for uncertainty processing in hierarchical decision making.Nature communications · 2025Article
- Probing Neural Compensation in Rehabilitation of Acute Ischemic Stroke with Lesion Network Similarity Using Resting State Functional MRI.Brain sciences · 2025Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Exploring the Potential of Voxel-Mirrored Homotopic Connectivity (VMHC) and Regional Homogeneity (ReHo) in Understanding Cognitive Changes After Heart Transplantation.Biomedicines · 2025Article
- A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia.Cell reports. Medicine · 2024Article
- Subcortical Aphasia: An Update.Current neurology and neuroscience reports · 2024Review
- Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum.Schizophrenia bulletin · 2024Article
- Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex.Journal of neurophysiology · 2024Article
- Long-Term Outcomes and Survival Rates of Patients Undergoing Biopsy Vs. Maximum Safe Resection for Thalamic Lesions: A Short Review on Current Evidence.Galen medical journal · 2024Review
- The impact of the human thalamus on brain-wide information processing.Nature reviews. Neuroscience · 2023Review
- White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control.Nature communications · 2023Article
- Involvement of Thalamocortical Networks in Patients With Poststroke Thalamic Aphasia.Neurology · 2023Article
- In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.Frontiers in neuroscience · 2023Article
- Functional and structural lesion network mapping in neurological and psychiatric disorders: a systematic review.Frontiers in neurology · 2023Article
- Article
- Central precuneus lesions are associated with impaired executive function.Brain structure & function · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The human thalamus has been suggested to be involved in executive function, based on animal studies and correlational evidence from functional neuroimaging in humans. Human lesion studies, examining behavioral deficits associated with focal brain injuries, can directly test the necessity of the human thalamus for executive function. The goal of our study was to determine the specific lesion location within the thalamus as well as the potential disruption of specific thalamocortical functional networks, related to executive dysfunction. We assessed executive function in 15 patients with focal thalamic lesions and 34 comparison patients with lesions that spared the thalamus. We found that patients with mediodorsal thalamic lesions exhibited more severe impairment in executive function when compared to both patients with thalamic lesions that spared the mediodorsal nucleus and to comparison patients with lesions outside the thalamus. Furthermore, we employed a lesion network mapping approach to map cortical regions that show strong functional connectivity with the lesioned thalamic subregions in the normative functional connectome. We found that thalamic lesion sites associated with more severe deficits in executive function showed stronger functional connectivity with ACC, dorsomedial PFC, and frontoparietal network, compared to thalamic lesions not associated with executive dysfunction. These are brain regions and functional networks whose dysfunction could contribute to impaired executive functioning. In aggregate, our findings provide new evidence that delineates a thalamocortical network for executive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.