Evidence map›Paper›PMID 32902259›Full record

ArticleACS chemical biology2020

Oligonucleotide Probe for Transcriptome

Sean B Yeldell, Linlin Yang, Jaehee Lee, James H Eberwine, Ivan J Dmochowski

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Ratiometric, pH-Sensitive Probe for Monitoring siRNA Delivery.Journal of the American Chemical Society · 2023
    Article
  3. Application of spatial transcriptome technologies to neurological diseases.Frontiers in cell and developmental biology · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Conditionally Activated ("Caged") Oligonucleotides.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sean B YeldellDepartment of Chemistry, University of Pennsylvania, 231 South 34 Street, Philadelphia, Pennsylvania 19104-6323, United States.
Linlin YangDepartment of Chemistry, University of Pennsylvania, 231 South 34 Street, Philadelphia, Pennsylvania 19104-6323, United States.
Jaehee LeeDepartment of Pharmacology, University of Pennsylvania, 38 John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, United States.
James H EberwineDepartment of Pharmacology, University of Pennsylvania, 38 John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, United States.
Ivan J DmochowskiDepartment of Chemistry, University of Pennsylvania, 231 South 34 Street, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0001-7162-1347
University of Pennsylvania · US

Funding

Designer Molecular Probes for Biomedical ApplicationsR35GM131907 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ivan Julian Dmochowski · 2019 to 2026
$4.7M
Oligonucleotides for turning genes on and off with lightR01GM083030 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DMOCHOWSKI, IVAN JULIAN · 2008 to 2017
$3.0M
NIGMS NIH HHS R01 GM083030NIGMS NIH HHS R35 GM131907
6 · The paper itself

Abstract

Messenger RNA (mRNA) isolated from single cells can generate powerful biological insights, including the discovery of new cell types with unique functions as well as markers potentially predicting a cell's response to various therapeutic agents. We previously introduced an oligonucleotide-based technique for site-selective, photoinduced biotinylation and capture of mRNA within a living cell called transcriptome

Indexed as

TranscriptomeAnimalsBiotinBrainCarbocyaninesFluorescent DyesGene Expression ProfilingLightMiceMicroscopy, ConfocalMicroscopy, FluorescenceNeuronsNitrobenzenesRNA, MessengerRNA ProbesSingle-Cell AnalysisBiotinCarbocyaninescyanine dye 3Fluorescent DyesNitrobenzenesRNA, MessengerRNA Probes

Identifiers

PMID32902259
PMCPMC8312762
OpenAlexW3084247708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.