ArticleCancer reports (Hoboken, N.J.)2020
Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters.
Article in Cancer reports (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- An easy-to-use nomogram predicting overall survival of adult acute lymphoblastic leukemia.Frontiers in oncology · 2022Article
- Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters.Cancer reports (Hoboken, N.J.) · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundRecurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR-ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR -ABL - is the commonest recurrent abnormality whereas, IgH rearrangements are rare.
aimAim of this study was to identify common recurrent genetic abnormalities in adult B ALL and study their association with hematological findings.
methodsBone marrow and peripheral blood from patients with B acute lymphoblastic leukemia were analyzed for complete blood counts, bone marrow morphology and cytogenetic abnormalities. The study group was divided into smaller groups based on cytogenetic abnormalities. Hematological parameters and presence of recurrent genetic abnormalities was compared across age groups and gender by non parametric tests.
resultsBCR-ABL positive group had a higher leukocyte count than BCR-ABL negative group. Among groups 1 to 5, group 1 with gains of chromosomes was associated with leucopenia and higher age at presentation. BCR-ABL is commonest recurrent abnormality followed by IgH rearrangements.
conclusionPatients with gains of chromosomes alone have low total leukocyte counts at presentation.
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