Observational studyJournal of diabetes investigation2021
Mediation effect of the duration of diabetes mellitus on the decrease in bioimpedance phase angles in ethnically Korean people: A multicenter clinical study.
Observational study in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Phase Angle as a Potential Screening Tool in Adults with Metabolic Diseases in Clinical Practice: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Bioelectrical phase angle predicts sarcopenia in older adults with type 2 diabetes mellitus.JBMR plus · 2026Article
- Phase Angle and Extracellular Water-to-Total Body Water Ratio Measured by Bioelectrical Impedance Analysis Are Associated with Anemia and Hemoglobin Levels in Women with Type 2 Diabetes: A Cross-Sectional Study.Health science reports · 2026Article
- Association Between Phase Angle and HbA1c in Non-elderly Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study Using Outpatient Clinical Data.Internal medicine (Tokyo, Japan) · 2026Article
- Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies.Nutrition & diabetes · 2026Article
- Comparison of clip and needle electrodes for multifrequency bioimpedance analysis in anesthetized dogs.PloS one · 2026Article
- Phase angle as a potential marker of early nutritional and metabolic changes following metabolic bariatric surgery: a retrospective study.Frontiers in nutrition · 2026Article
- Phase Angle Evaluated by a Bioimpedance Analysis Is Closely Related to Diabetic Nephropathy and Peripheral Neuropathy in Patients with Type 2 Diabetes.JMA journal · 2025Article
- Article
- Phase angle is a useful predicting indicator for protein-energy wasting and cardiovascular risk among maintenance hemodialysis patients.Scientific reports · 2024Observational
- Agreement Between Bioelectrical Impedance Analysis and Dual-Energy X-ray Absorptiometry to Estimate Fat Mass in Hispanic Adults With Type 2 Diabetes Mellitus: A Cross-Sectional Study.Clinical medicine insights. Endocrinology and diabetes · 2024Article
- Design and clinical application of a risk prediction model for diabetic foot.American journal of translational research · 2024Article
- Determinants of phase angle in Japanese patients with diabetes.Diabetology international · 2023Article
- Article
- Mediation effect of the duration of diabetes mellitus on the decrease in bioimpedance phase angles in ethnically Korean people: A multicenter clinical study.Journal of diabetes investigation · 2021Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionWe carried out a multicenter clinical study to investigate whether the decrease in segmental phase angles (PhA values) observed using bioelectrical impedance is useful in screening for diabetes mellitus and monitoring disease progression. MATERIALS AND
methodsThe segmental PhA values of the four limbs were acquired using multifrequency bioimpedance at 5, 50 and 250 kHz in three clinics. Differences in PhA values between the diabetes and control groups were analyzed using the two-sample t-test and analysis of variance (anova). Changes in PhA values with increasing durations of diabetes were analyzed using a moderated mediation model and multivariate linear regression analysis. We recruited 217 participants aged ≥40 years (diabetes 158, controls 59, men 106, women 111, A-clinic 71, B-clinic 70 and C-clinic 76).
resultsPhA values at 50 kHz were significantly decreased in people with diabetes (PhA of the right arm in men: t-value -4.0, P < 0.001; PhA of the right leg in women: t-value -4.6 P < 0.001), and the difference was partially attributable to the duration of diabetes, as well as aging. Specifically, the mediation effect of the duration of diabetes on the decrease in PhA values was 29.8% in the left arm of men, 53.3% in the right arm of women, and 36.3% in the left arm of both sexes.
conclusionsPhase angle values at 50 kHz decreased in people with diabetes, and the changes were exacerbated as the disease duration increased. Thus, bioimpedance PhA values represent a non-invasive tool for monitoring the progression of diabetes mellitus.
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Registered trials
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