Evidence map›Paper›PMID 32902003›Full record

ReviewChemistry (Weinheim an der Bergstrasse, Germany)2021

High-Z Metal-Organic Frameworks for X-ray Radiation-Based Cancer Theranostics.

Megan J Neufeld, Alec Lutzke, Guillem Pratx, Conroy Sun

Open access · bronzeAbstract readReview
In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Fe/Pharmaceutics · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Selective CONature communications · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Megan J NeufeldDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.ORCID http://orcid.org/0000-0003-0812-2208
Alec LutzkeBeckman Coulter Life Sciences, Loveland, CO, 80538, USA.
Guillem PratxDepartment of Radiation Oncology, Stanford University, Stanford, California, 94305, USA.ORCID http://orcid.org/0000-0002-0247-6470
Conroy SunDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, 97201, USA.ORCID http://orcid.org/0000-0001-5193-6907
Oregon State University · USBeckman Coulter Foundation · USStanford Medicine · US

Funding

Synergistic combination of nanotechnology and radiation in medicineR35GM119839 · NIGMS · OREGON STATE UNIVERSITY · PI SUN, CONROY GHIN CHEE · 2016 to 2020
$1.8M
NIGMS NIH HHS R35 GM119839NIH HHS 1R35GM119839-01
6 · The paper itself

Abstract

X-ray radiation is commonly employed in clinical practice for diagnostic and therapeutic applications. Over the past decade, developments in nanotechnology have led to the use of high-Z elements as the basis for innovative new treatment platforms that enhance the clinical efficacy of X-ray radiation. Nanoscale metal-frameworks (nMOFs) are coordination networks containing organic ligands that have attracted attention as therapeutic platforms in oncology and other areas of medicine. In cancer therapy, X-ray activated, high-Z nMOFs have demonstrated potential as radiosensitizers that increase local radiation dose deposition and generation of reactive oxygen species (ROS). This minireview summarizes current research on high-Z nMOFs in cancer theranostics and discusses factors that may influence future clinical application.

Indexed as

NeoplasmsHumansMetal-Organic FrameworksNanostructuresPrecision MedicineX-RaysMetal-Organic Frameworksbiomedical imagingcancer theranosticsmetal-organic frameworksnanomedicineradiation

Identifiers

PMID32902003
PMCPMC7887037
OpenAlexW3084414463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.