Evidence map›Paper›PMID 32901981›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

μ-Lat: A mouse model to evaluate human immunodeficiency virus eradication strategies.

Hannah S Sperber, Padma Priya Togarrati, Kyle A Raymond, Mohamed S Bouzidi, Renata Gilfanova, Alan G Gutierrez, Marcus O Muench, Satish K Pillai

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah S SperberVitalant Research Institute, San Francisco, CA, USA.
Padma Priya TogarratiVitalant Research Institute, San Francisco, CA, USA.
Kyle A RaymondVitalant Research Institute, San Francisco, CA, USA.
Mohamed S BouzidiVitalant Research Institute, San Francisco, CA, USA.
Renata GilfanovaVitalant Research Institute, San Francisco, CA, USA.
Alan G GutierrezVitalant Research Institute, San Francisco, CA, USA.
Marcus O MuenchVitalant Research Institute, San Francisco, CA, USA.
Satish K PillaiVitalant Research Institute, San Francisco, CA, USA.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Effects of Human Galectin-9 on the CNS HIV ReservoirR01MH112457 · NIMH · VITALANT · PI NDHLOVU, LISHOMWA C, PILLAI, SATISH KUMAR · 2016 to 2020
$2.0M
Effects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV LatencyR01GM117901 · NIGMS · VITALANT · PI PILLAI, SATISH KUMAR · 2015 to 2018
$1.5M
Effects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV LatencyR01AI150449 · NIAID · VITALANT · PI PILLAI, SATISH KUMAR · 2019 to 2019
$305k
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI150449NIGMS NIH HHS R01 GM117901NIMH NIH HHS R01 MH112457
6 · The paper itself

Abstract

A critical barrier to the development of a human immunodeficiency virus (HIV) cure is the lack of a scalable animal model that enables robust evaluation of eradication approaches prior to testing in humans. We established a humanized mouse model of latent HIV infection by transplanting "J-Lat" cells, Jurkat cells harboring a latent HIV provirus encoding an enhanced green fluorescent protein (GFP) reporter, into irradiated adult NOD.Cg-Prkdc

Indexed as

Disease Models, AnimalVirus LatencyAnimalsBone MarrowCell TransplantationFemaleGreen Fluorescent ProteinsHIVHIV InfectionsHumansJurkat CellsLungMaleMiceMice, Inbred NODProvirusesGreen Fluorescent Proteinsantiviral gene therapyHIVHIV latencyhumanized mouselatency reversalshock and kill

Identifiers

PMID32901981
PMCPMC8787083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.