Evidence map›Paper›PMID 32901956›Full record

ArticleThe EMBO journal2020

Molecular basis for the bifunctional Uba4-Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation.

Marta Pabis, Martin Termathe, Keerthiraju E Ravichandran, Sandra D Kienast, Rościsław Krutyhołowa, Mikołaj Sokołowski, Urszula Jankowska, Przemysław Grudnik, Sebastian A Leidel, Sebastian Glatt

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Chemical Tools for Probing the Ub/Ubl Conjugation Cascades.Chembiochem : a European journal of chemical biology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Biosynthesis and Degradation of Sulfur Modifications in tRNAs.International journal of molecular sciences · 2021
    Review
  16. Urm1, not quite a ubiquitin-like modifier?Microbial cell (Graz, Austria) · 2021
    Article
  17. Urm1: A Non-Canonical UBL.Biomolecules · 2021
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Marta Pabis *Malopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0001-7394-5206
Martin Termathe *Max Planck Institute for Molecular Biomedicine, Muenster, Germany.ORCID 0000-0002-5618-4633
Keerthiraju E Ravichandran *Malopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0003-2568-1343
Sandra D KienastMax Planck Institute for Molecular Biomedicine, Muenster, Germany.
Rościsław KrutyhołowaMalopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0002-8200-5627
Mikołaj SokołowskiMalopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0002-1016-555X
Urszula JankowskaMalopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0002-7165-8964
Przemysław GrudnikMalopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0002-7157-0014
Sebastian A LeidelMax Planck Institute for Molecular Biomedicine, Muenster, Germany.ORCID 0000-0002-0523-6325
Sebastian GlattMalopolska Centre of Biotechnology (MCB), Jagiellonian University, Krakow, Poland.ORCID 0000-0003-2815-7133
Jagiellonian University · PLUniversity of Bern · CHMax Planck Institute for Molecular Biomedicine · DE

Funding

EC | Horizon 2020 Framework Programme (H2020) 730872Fundacja na rzecz Nauki Polskiej (FNP) FirstTEAM/2016-1/2Fundacja na rzecz Nauki Polskiej (FNP) TEAM TECH CORE FACILITY/2017-4/6Narodowe Centrum Nauki (NCN) 2018/31/B/NZ1/03559Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) NCCR RNA & Disease
6 · The paper itself

Abstract

The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin-related modifier 1 (Urm1) pathway is responsible for the synthesis of 2-thiolated wobble uridine (U

Indexed as

HumansNucleotidyltransferasesRNA, TransferSulfurSulfurtransferasesUbiquitinsMOCS3 protein, humanNucleotidyltransferasesRNA, TransferSulfurSulfurtransferasesUbiquitinsUrm1 protein, humanadenylationthioesterthiolationtRNA modificationubiquitin-like proteins

Identifiers

PMID32901956
PMCPMC7527816
OpenAlexW3084389021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.