Evidence map›Paper›PMID 32901682›Full record

ArticleActa cirurgica brasileira2020

Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats.

Bruno Cesar Schimming, Mucio Luiz de Assis Cirino, Fermino Sanches Lizarte Neto, Paulo Cezar Novais, Camila Albuquerque Melo de Carvalho, Daniela Pretti da Cunha Tirapelli, Carlos Augusto Fernandes Molina, Luis Fernando Tirapelli, Silvio Tucci Junior

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Bruno Cesar SchimmingPhD, Associate Professor, Department of Anatomy, Biosciences Institute of Botucatu, Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil. Technical procedures, interpretation of data, statistical analysis, manuscript preparation, critical revision.ORCID http://orcid.org/0000-0002-0837-9612
Mucio Luiz de Assis CirinoFellow PhD degree, Postgraduate Program in Surgical Clinic, Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirao Preto-SP, Brazil. Acquisition and interpretation of data, statistical analysis.ORCID http://orcid.org/0000-0001-7872-8331
Fermino Sanches Lizarte NetoPhD, Department of Surgery and Anatomy, Surgical Clinic Program, FMRP-USP, Ribeirao Preto-SP, Brazil. Acquisition and interpretation of data, statistical analysis, critical revision.ORCID http://orcid.org/0000-0002-0046-7300
Paulo Cezar NovaisPhD, Department of Odontology, Universidade de Marília (UNIMAR), Marilia-SP, Brazil. Acquisition and interpretation of data, statistical analysis.ORCID http://orcid.org/0000-0001-8372-6293
Camila Albuquerque Melo de CarvalhoPhD, Department of Surgery and Anatomy, FMRP-USP, Assistant Professor, Centro Universitário Barão de Mauá, Ribeirao Preto-SP, Brazil. Acquisition and interpretation of data, statistical analysis.ORCID http://orcid.org/0000-0003-2325-2844
Daniela Pretti da Cunha TirapelliPhD, Assistant Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Conception and design of the study, critical revision.ORCID http://orcid.org/0000-0002-1886-4988
Carlos Augusto Fernandes MolinaPhD, Assistant Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Conception and design of the study, critical revision.ORCID http://orcid.org/0000-0002-5118-778X
Luis Fernando TirapelliPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Conception and design of the study, critical revision.ORCID http://orcid.org/0000-0002-2251-1106
Silvio Tucci JuniorPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Conception and design of the study, critical revision, supervised all phases.ORCID http://orcid.org/0000-0002-7656-0181
Universidade de Ribeirão Preto · BRCentro Universitário Barão de Mauá · BRClinics Hospital of Ribeirão Preto · BRJP Group (Brazil) · BRUniversidade de Marília · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of alcohol exposure and diabetes on apoptotic process in the corpus cavernosum.

methodsForty eight male Wistar rats were divided into four groups: control, diabetic, alcoholic and diabetic-alcoholic. Samples of the corpus cavernosum were prepared to study protein expression of apoptotic genes (Caspases-3 and 9) by immunohistochemistry and Real-Time PCR.

resultsThe immunoreactivity of Caspases-3 and -9 was diffuse and higher in the treated groups though there was no significant difference between the experimental groups, only when compared with the control group. An increase was observed in the gene expression of Caspases-9 in the diabetic and ethanol-diabetic groups when compared with control and ethanol groups.

conclusionsThe association of these factors (ethanol and diabetes) probably can affect the apoptosis mechanism in lesions of the cavernous tissue in the rat penis. Both gene and protein expression of Caspase-9 in diabetic and ethanol-diabetic groups suggest the involvement of the apoptosis cascade from this study model.

Indexed as

AlcoholismApoptosisDiabetes Mellitus, ExperimentalAnimalsMalePenisRatsRats, Wistar

Identifiers

PMID32901682
PMCPMC7478468
OpenAlexW3084313223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.