Evidence map›Paper›PMID 32901612›Full record

ArticleeLife2020

Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity.

Tarun Kumar, Leo Blondel, Cassandra G Extavour

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  6. Journal of biosciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tarun Kumar *Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-4071-4342
Leo Blondel *Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-2276-4821
Cassandra G ExtavourDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-2922-5855
Harvard University · US

Funding

Genetic regulation of ovariole development in DrosophilaR01HD073499 · NICHD · HARVARD UNIVERSITY · PI EXTAVOUR, CASSANDRA G · 2013 to 2017
$1.8M
NICHD NIH HHS R01 HD073499NIH HHS 1R01-HD073499
6 · The paper itself

Abstract

Understanding the genetic regulation of organ structure is a fundamental problem in developmental biology. Here, we use egg-producing structures of insect ovaries, called ovarioles, to deduce systems-level gene regulatory relationships from quantitative functional genetic analysis. We previously showed that Hippo signalling, a conserved regulator of animal organ size, regulates ovariole number in

Indexed as

Protein Interaction MapsAnimalsDrosophila melanogasterDrosophila ProteinsFemaleGene Regulatory NetworksHippo KinasesIntracellular Signaling Peptides and ProteinsMaleOvipositionProtein Serine-Threonine KinasesSignal TransductionDrosophila ProteinsHippo Kinaseshpo protein, DrosophilaIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine Kinasescomputational biologydevelopmental biologyD. melanogasterHippo signallinginteractomenetwork analysisovarioleovaryreproductionsystems biology

Identifiers

PMID32901612
PMCPMC7550192
OpenAlexW3084150415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.