ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020
Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
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Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Effect of mesenchymal stromal cell infusions on lung function in COPD patients with high CRP levels.Respiratory research · 2021Trial
- The PPARβ/Delta-Induced Mesenchymal Stromal Cell Secretome Has Cytoprotective Effects via ANGPTL4 in a Pre-Clinical Model of Acute Lung Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- IL-1β modulates inflammatory response of human bone marrow-derived MSCs and neutrophil recruitment in vitro via NF-kB-associated signaling.Stem cell research & therapy · 2026Article
- Antigenemia and oral lesions in paracoccidioidomycosis: is there a correlation?Journal of applied oral science : revista FOB · 2026Article
- How the Fibrotic Lung Microenvironment Regulates Stem Cell Behavior: Immune Cues, Extracellular Matrix Remodeling, and Therapeutic Implications.Analytical cellular pathology (Amsterdam) · 2026Review
- Cardioprotective effects of extracellular vesicles from hypoxia-preconditioned mesenchymal stromal cells in experimental pulmonary arterial hypertension.Stem cell research & therapy · 2025Article
- Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs.Cytotherapy · 2025Article
- The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Human Mesenchymal Stem Cell (hMSC) Donor Potency Selection for the "First in Cystic Fibrosis" Phase I Clinical Trial (CEASE-CF).Pharmaceuticals (Basel, Switzerland) · 2023Article
- Functional enhancement strategies to potentiate the therapeutic properties of mesenchymal stromal cells for respiratory diseases.Frontiers in pharmacology · 2023Review
- What is the need and why is it time for innovative models for understanding lung repair and regeneration?Frontiers in pharmacology · 2023Review
- MSCs interaction with the host lung microenvironment: An overlooked aspect?Frontiers in immunology · 2022Review
- Secondary Lymphoid Organs in Mesenchymal Stromal Cell Therapy: More Than Just a Filter.Frontiers in immunology · 2022Review
- Sweat metabolomics before and after intravenous antibiotics for pulmonary exacerbation in people with cystic fibrosis.Respiratory medicine · 2022Article
- Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.Intensive care medicine experimental · 2021Review
- Promises and challenges of personalized medicine to guide ARDS therapy.Critical care (London, England) · 2021Review
- Review
- HealthyThe European respiratory journal · 2021Article
Corrections and comments
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Authors and funding
24 authors at 9 institutions in 7 countries.
Soraia C AbreuDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Thomas H HamptonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.ORCID 0000-0003-0543-402X
Evan HoffmanDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Jacob DearbornDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Alix AshareDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Karatatiwant Singh SidhuDepartment of Chemistry, University of Vermont, Burlington, Vermont.
Dwight E MatthewsDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
David H McKennaDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Eyal AmielDepartment of Biomedical and Health Sciences, College of Nursing and Health Sciences, University of Vermont, Burlington, Vermont.ORCID 0000-0002-1578-8705
Jayita BaruaDivision of Pulmonary Disease and Critical Care, University of Vermont, and The Vermont Lung Center, Burlington, Vermont.
Anna KrasnodembskayaWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast, Belfast, United Kingdom.ORCID 0000-0002-2380-5069
Karen EnglishCellular Immunology Laboratory, Biology Department, Human Health Research Institute, Maynooth University, Maynooth, Ireland.
Bernard MahonImmunology & Cell Biology Laboratory, Biology Department, Human Health Research Institute, Maynooth University, Maynooth, Ireland.ORCID 0000-0003-1538-7490
Claudia Dos SantosDepartments of Medicine and Critical Care Medicine and the Keenan Research Center for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Fernanda F CruzLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Daniel C ChambersSchool of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Kathleen D LiuDepartments of Medicine and Anesthesiology and the Cardiovascular Research Institute, University of California, San Francisco, California.
Michael A MatthayDepartments of Medicine and Anesthesiology and the Cardiovascular Research Institute, University of California, San Francisco, California.
Robert A CramerDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Bruce A StantonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Patricia R M RoccoLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Matthew J WargoDepartment of Microbiology & Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Daniel J WeissDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Sara Rolandsson EnesDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.
University of Vermont · USDartmouth College · USNational University of Ireland, Maynooth · IEUniversidade Federal do Rio de Janeiro · BRUniversity of California, San Francisco · USQueen's University Belfast · GBSt. Michael's Hospital · CAThe University of Queensland · AUUniversity of Minnesota · US
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MTranslational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9MVermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8MEvolution of Aspergillus fumigatus virulenceR01AI130128 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2017 to 2026
$4.5MHypoxia Adaptation and Fungal Virulence of Aspergillus fumigatusR01AI081838 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI CRAMER, ROBERT ANDREW · 2009 to 2017
$2.9MPrevention and Early Treatment of Acute Lung InjuryU01HL123004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2014 to 2020
$2.6MRegional Hypoxia Impacts the Heterogeneity of Inflammatory Lung DiseaseR01HL122372 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2015 to 2019
$2.0MMacrophage Pathogen Interactions in Regional Cystic Fibrosis Lung InflammationK24HL150453 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2020 to 2024
$542kMedical Research Council MR/L017229/1Medical Research Council MR/R025096/1Medical Research Council MR/S009426/1NCI NIH HHS P30 CA023108NHLBI NIH HHS K24 HL150453NHLBI NIH HHS R01 HL122372NHLBI NIH HHS U01 HL123004NIAID NIH HHS R01 AI081838NIAID NIH HHS R01 AI130128NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P30 GM118228NIH HHS grant P30 GM118228NIH HHS HL123004,140026,and 126456
Abstract
Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the effects of ex vivo MSC exposure to clinical bronchoalveolar lavage fluid (BALF) samples, as a surrogate for the in vivo clinical lung environment, on MSC viability, gene expression, secreted cytokines, and mitochondrial function were compared with effects of BALF collected from healthy volunteers. CF BALF samples that cultured positive for
Indexed as
Mesenchymal Stem Cell TransplantationAnti-Inflammatory AgentsBronchoalveolar Lavage FluidCystic FibrosisHumansLungMesenchymal Stem CellsAnti-Inflammatory AgentsAspergillus infectioncell therapycystic fibrosisgliotoxinmesenchymal stromal cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.