Evidence map›Paper›PMID 32901520›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs.

Amrit Kumar Shrestha, Renuka T Menon, Ahmed El-Saie, Roberto Barrios, Corey Reynolds, Binoy Shivanna

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

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  19. EndothelialAntioxidants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amrit Kumar ShresthaSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-4972-5497
Renuka T MenonSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Ahmed El-SaieSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Roberto BarriosDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Corey ReynoldsMouse Phenotyping Core, Baylor College of Medicine, Houston, Texas.
Binoy ShivannaSection of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Baylor College of Medicine · USMethodist Hospital · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Consortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0M
Mechanistic Roles of Adrenomedullin and its Signaling Receptors in Experimental Bronchopulmonary Dysplasia and Pulmonary HypertensionR01HL139594 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI SHIVANNA, BINOY · 2018 to 2022
$2.0M
National Institutes of Heath P30DK056338NHGRI NIH HHS U54 HG006348NHLBI NIH HHS R01 HL139594NIDDK NIH HHS P30 DK056338NIH HHS HL139594NIH HHS U54 HG006348
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) is a chronic infantile lung disease that lacks curative therapies. Infants with BPD-associated PH are often exposed to hyperoxia and additional insults such as sepsis that contribute to disease pathogenesis. Animal models that simulate these scenarios are necessary to develop effective therapies; therefore, we investigated whether lipopolysaccharide (LPS) and hyperoxia exposure during saccular lung development cooperatively induce experimental BPD-PH in mice. C57BL/6J mice were exposed to normoxia or 70% O

Indexed as

AnimalsCell ProliferationDisease Models, AnimalHyperoxiaHypertension, PulmonaryInflammationLipopolysaccharidesLungMice, Inbred C57BLVascular RemodelingLipopolysaccharidesbronchopulmonary dysplasiahyperoxiainflammationlipopolysaccharidepulmonary hypertension

Identifiers

PMID32901520
PMCPMC7792686
OpenAlexW3084251770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.