ArticleEpigenomics2020
Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
Open access · greenAbstract read
In one paragraph
Article in Epigenomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population.Clinical epigenetics · 2024Pooled it
- Genome-Wide Association Study on the Estimated Breeding Values for Udder and Longevity and the Candidate Genes in Holstein-Friesian Cows in Hungary.Animals : an open access journal from MDPI · 2025Article
- Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease.Epigenomics · 2025Review
- DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts.American journal of human genetics · 2025Article
- Methylome-wide studies of six metabolic traits.medRxiv : the preprint server for health sciences · 2024Article
- Genetics and Epigenetics in Obesity: What Do We Know so Far?Current obesity reports · 2023Review
- Epigenome-wide association study of plasma lipids in West Africans: the RODAM study.EBioMedicine · 2023Article
- DNA methylation-based predictors of health: applications and statistical considerations.Nature reviews. Genetics · 2022Review
- Lipid Phenotypes and DNA Methylation: a Review of the Literature.Current atherosclerosis reports · 2021Review
- Distinct Associations of BMI and Fatty Acids With DNA Methylation in Fasting and Postprandial States in Men.Frontiers in genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 13 institutions in 3 countries.
Anne E JusticeDepartment of Population Health Sciences, Geisinger, Danville, PA 17822, USA.ORCID 0000-0002-8903-8712
Geetha ChittoorDepartment of Population Health Sciences, Geisinger, Danville, PA 17822, USA.
Rahul GondaliaDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Phillip E MeltonSchool of Biomedical Science, Faculty of Health & Medical Sciences, The University of Western Australia, Perth, WA 6000, Australia.
Elise LimDepartment of Biostatistics, Boston University, Boston, MA 02118, USA.
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University, Boston, MA 02118, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University, Boston, MA 02118, USA.
Lindsay Fernandez-RhodesDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Weihua GuanDivision of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA.
Jan BresslerHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Myriam FornageCenter for Human Genetics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Yun LiDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ellen DemerathDivision of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN 55455, USA.
Nancy Heard-CostaFramingham Heart Study, Framingham, MA, 01701, USA.
Dan LevyPopulation sciences branch, NHLBI Framingham Heart Study, Framingham, MA 01702, USA.
James D StewartDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Andrea BaccarelliLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences & Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, USA.
Karen ConneelyDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Trevor A MoriMedical School, University of Western Australia, Perth, Australia.
Lawrence J BeilinMedical School, University of Western Australia, Perth, Australia.
Rae-Chi HuangTelethon Kids Institute, University of Western Australia, Perth, Australia.
Penny Gordon-LarsenDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC 27599, USA.
Annie Green HowardDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USBoston University · USThe University of Texas Health Science Center at Houston · USThe University of Western Australia · AUUniversity of Minnesota · USBaylor College of Medicine · USCenter for Human Genetics · USColumbia University · USEmory University · USGeisinger Health System · USNorthwestern University · USThe Kids Research Institute Australia · AUUniversity of Tasmania · AU
Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MLeveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9MPAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5MEpigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0MAn Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel DiseaseR01NS087541 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A., FORNAGE, MYRIAM · 2014 to 2017
$2.5MStatistical Methods in Trans-Omics Chronic Disease ResearchR01HG009974 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2018 to 2022
$1.5MSex- and Smoking- Specific DNA Methylation Signatures of Central Adiposity ChangeR00HL130580 · NHLBI · GEISINGER CLINIC · PI JUSTICE, ANNE · 2017 to 2019
$745kSex- and Smoking- Specific DNA Methylation Signatures of Central Adiposity ChangeK99HL130580 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JUSTICE, ANNE · 2016 to 2017
$217kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHGRI NIH HHS R01 HG009974NHGRI NIH HHS R01 HG010297NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K99 HL130580NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL143885NHLBI NIH HHS RC2 HL102419NIEHS NIH HHS R01 ES020836NINDS NIH HHS R01 NS087541
Abstract
PubMed holds no abstract for this paper.
Indexed as
DNA MethylationEpigenesis, GeneticEpigenomicsAdiposityCohort StudiesCpG IslandsDisease SusceptibilityEndocrine SystemGenome-Wide Association StudyHumansImmune SystemObesityancestrally diversebody fat distributioncardiometabolic diseasecentral adiposityDNA methylationmethylome-wide association studyTXNIPwaist circumferencewaist-to-height ratiowaist-to-hip ratio
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.