ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Comparison of planar with tomographic pyrophosphate scintigraphy for transthyretin cardiac amyloidosis: Perils and pitfalls.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Diagnostic performance of CMR, SPECT, and PET imaging for the detection of cardiac amyloidosis: a meta-analysis.BMC cardiovascular disorders · 2021Pooled it
- Agreement between SPECT/CT-derived autoplanar imaging and conventional planar imaging inAnnals of nuclear medicine · 2026Article
- Chest X-ray-guided SPECT-only quantification as an adjunctive approach for wild-type transthyretin amyloid cardiomyopathy.Heart and vessels · 2026Article
- Diagnostic and prognostic value ofEJNMMI reports · 2026Article
- Cardiac Amyloidosis: Tribulations and New Frontiers.Journal of personalized medicine · 2025Review
- Myocardium-to-cavity ratio derived from simultaneousEJNMMI reports · 2025Article
- Impact of Region of Interest Size on Semi-Quantification of MyocardialAnnals of nuclear cardiology · 2025Article
- From Molecular to Radionuclide and Pharmacological Aspects in Transthyretin Cardiac Amyloidosis.International journal of molecular sciences · 2024Review
- Evolution of cardiac amyloidosis imaging with bone-avid tracers: From qualification to quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Article
- Appraisal of amyloidosis imaging practices in the Middle East/North Africa (PYP-MENA).European heart journal. Imaging methods and practice · 2024Article
- Current barriers and recommendations on the diagnosis of transthyretin amyloid cardiomyopathy: a Delphi study.Frontiers in cardiovascular medicine · 2024Article
- A Quantitative Diagnostic Method UsingAnnals of nuclear cardiology · 2024Article
- Lateral Planar Imaging ofAnnals of nuclear cardiology · 2024Article
- Lights and Shadows of Clinical Applications of Cardiac Scintigraphy with Bone Tracers in Suspected Amyloidosis.Journal of clinical medicine · 2023Review
- Comparison of cardio-focal and chest reconstruction of technetium-99m pyrophosphate scintigraphy for diagnosis of transthyretin cardiac amyloidosis: a quality assurance study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Single photon emission computed tomography pyrophosphate imaging for transthyretin cardiac amyloid.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Direct comparison of diagnostic and clinical values between Tc-99 m DPD and Tc-99 m PYP scintigraphy in patients with cardiac amyloidosis.BMC medical imaging · 2023Article
- ASNC SPECT-MPI quality metrics: a race to the top.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Echocardiographic indices of left ventricular function and filling pressure are not related to blood pool activity on pyrophosphate scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Multimodality imaging for diagnosis of subclinical hereditary transthyretin cardiac amyloidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTc-99m pyrophosphate (PYP) SPECT is recommended for indeterminate findings on planar imaging. We aimed to compare the findings on planar PYP scintigraphy alone to that of routinely performed PYP SPECT.
methodsPYP scintigraphy data of 133 patients (53% men; mean age 76 years) were evaluated. SPECT was routinely performed following 1-hour planar imaging, in all cases. Semiquantitative visual score and heart-to-contralateral (H/CL) ratio were determined in all patients as recommended.
resultsPYP images from 35 patients (26%) were considered to be positive based on SPECT myocardial uptake. Among them, 20 (57%) had a H/CL ratio ≥1.5 and 34 had a visual score ≥ 2. SPECT identified myocardial uptake in one patient with a visual score < 2 and refuted the presence of myocardial uptake in two patients with a visual score ≥ 2. Visual score correlated well with SPECT (r = 0.94; P < .0001) and had an accuracy of 98% for tomographic myocardial uptake. Addition of H/CL ratio reduced the diagnostic performance of visual score.
conclusionsPlanar-derived visual score has an excellent accuracy for tomographic myocardial uptake, though it misclassifies a small proportion of patients. H/CL ratio decreases the diagnostic certainty of planar imaging. Tomographic imaging prevents misdiagnoses and should always be performed.
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