Evidence map›Paper›PMID 32901137›Full record

ArticleBritish journal of cancer2020

EGFR as a stable marker of prostate cancer dissemination to bones.

Paulina Nastały, Sara Stoupiec, Marta Popęda, Julia Smentoch, Thorsten Schlomm, Colm Morrissey, Anna Joanna Żaczek, Burkhard Beyer, Pierre Tennstedt, Markus Graefen and 6 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  11. Increased ErbB2 Signaling Is an Early Adaptation to Androgen Signaling Inhibition and Persists in Castration-Resistant Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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  12. Design, synthesis, andRSC advances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Paulina Nastały *Laboratory of Translational Oncology, Institute of Medical Biotechnology and Experimental Oncology, Medical University of Gdańsk, Gdańsk, Poland.
Sara Stoupiec *Department of Tumour Biology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Marta PopędaLaboratory of Translational Oncology, Institute of Medical Biotechnology and Experimental Oncology, Medical University of Gdańsk, Gdańsk, Poland.
Julia SmentochLaboratory of Translational Oncology, Institute of Medical Biotechnology and Experimental Oncology, Medical University of Gdańsk, Gdańsk, Poland.
Thorsten SchlommDepartment of Urology, Charité University Hospital Berlin, Berlin, Germany.
Colm MorrisseyDepartment of Urology, University of Washington, Seattle, WA, USA.
Anna Joanna ŻaczekLaboratory of Translational Oncology, Institute of Medical Biotechnology and Experimental Oncology, Medical University of Gdańsk, Gdańsk, Poland.
Burkhard BeyerMartini-Clinic, Prostate Cancer Center and Section for Translational Prostate Cancer Research at the Clinic of Urology at University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Pierre TennstedtMartini-Clinic, Prostate Cancer Center and Section for Translational Prostate Cancer Research at the Clinic of Urology at University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Markus GraefenMartini-Clinic, Prostate Cancer Center and Section for Translational Prostate Cancer Research at the Clinic of Urology at University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Elke EltzeInstitute of Pathology Saarbruecken-Rastpfuhl, Saarbruecken, Germany.
Paolo MaiuriFIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology (IFOM), Milan, Italy.
Axel SemjonowDepartment of Urology, Prostate Center University Clinic Münster, Münster, Germany.
Klaus PantelDepartment of Tumour Biology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-5736-2772
Burkhard BrandtUniversity Medical Centre Schleswig-Holstein, Kiel, Germany.
Natalia Bednarz-KnollLaboratory of Translational Oncology, Institute of Medical Biotechnology and Experimental Oncology, Medical University of Gdańsk, Gdańsk, Poland. nbk@gumed.edu.pl.
Universität Hamburg · DEGdańsk Medical University · PLIFOM · ITCharité - Universitätsmedizin Berlin · DEUniversity Hospital Münster · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Washington · US

Funding

Narodowe Centrum Nauki (National Science Centre) 2017/01/X/NZ4/02120
6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is among the most commonly diagnosed malignancies in men. Although 5-year survival in patients with localised disease reaches nearly 100%, metastatic disease still remains incurable. Therefore, there is a need for markers indicating metastatic dissemination.

methodsEGFR overexpression (EGFR

resultsEGFR

conclusionsEGFR

Indexed as

Biomarkers, TumorBone NeoplasmsCell MovementCollagen Type ICollagen Type I, alpha 1 ChainEpithelial-Mesenchymal TransitionErbB ReceptorsFeasibility StudiesFlow CytometryHumansImmunohistochemistryMaleNeoplastic Cells, CirculatingProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantVimentinBiomarkers, TumorCollagen Type ICollagen Type I, alpha 1 ChainEGFR protein, humanErbB ReceptorsVimentin

Identifiers

PMID32901137
PMCPMC7722745
OpenAlexW3083885734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.