Evidence map›Paper›PMID 32901135›Full record

ReviewBritish journal of cancer2021

Cancer health disparities in racial/ethnic minorities in the United States.

Valentina A Zavala, Paige M Bracci, John M Carethers, Luis Carvajal-Carmona, Nicole B Coggins, Marcia R Cruz-Correa, Melissa Davis, Adam J de Smith, Julie Dutil, Jane C Figueiredo and 21 more

Abstract readReview
In one paragraph

Review in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 559 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
559citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

559 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  7. Racial and Ethnic Disparities in Survival among Patients with Cholangiocarcinoma in the United States: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Pooled it
  8. Ethnic disparities in survival and progression among EGFR-mutated adenocarcinoma of lung cancer patients treated with tyrosine kinase inhibitors: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
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  11. Observational
  12. Article
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  17. Embedding Community Engagement in Underrepresented Student Cancer Research Training Programs: A Preliminary Report.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article
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  20. Simulating the Impact of Zoning Policies on Equitably Reducing Neighborhood Tobacco Retailer Availability.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
    Article

499 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Valentina A ZavalaDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
John M CarethersDepartments of Internal Medicine and Human Genetics, and Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Luis Carvajal-CarmonaUniversity of California Davis Comprehensive Cancer Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA, USA.ORCID http://orcid.org/0000-0001-7129-2918
Nicole B CogginsGenome Center, University of California Davis, Davis, CA, USA.
Marcia R Cruz-CorreaDepartment of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.
Melissa DavisDivision of Breast Surgery, Department of Surgery, NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA.
Adam J de SmithCenter for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Julie DutilCancer Biology Division, Ponce Research Institute, Ponce Health Sciences University, Ponce, Puerto Rico.
Jane C FigueiredoSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rena FoxDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kristi D GravesDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Scarlett Lin GomezDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Andrea LleraLaboratorio de Terapia Molecular y Celular, IIBBA, Fundación Instituto Leloir, CONICET, Buenos Aires, Argentina.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Lisa NewmanDivision of Breast Surgery, Department of Surgery, NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY, USA.
Tung NguyenDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA, USA.
Nynikka R PalmerDepartment of Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California, San Francisco, San Francisco, CA, USA.
Eliseo J Pérez-StableDivision of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Sorbarikor PiawahDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Erik J RodriquezDivision of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
María Carolina Sanabria-SalasSubdirección de Investigaciones - Instituto Nacional de Cancerología de Colombia, Bogotá, Colombia.
Stephanie L SchmitDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Silvia J Serrano-GomezGrupo de investigación en biología del cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia.
Mariana C SternDepartments of Preventive Medicine and Urology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Jeffrey WeitzelDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Jun J YangDepartment of Pharmaceutical Sciences, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-0770-9659
Jovanny ZabaletaDepartment of Pediatrics and Stanley S. Scott Cancer Center LSUHSC, New Orleans, LA, USA.
Elad ZivDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Laura FejermanDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. laura.fejerman@ucsf.edu.ORCID http://orcid.org/0000-0003-3179-1151

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
A Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., RIVERA, ADELMA · 2012 to 2018
$23.2M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KENNETH Lynn WRIGHT · 2012 to 2026
$23.1M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Harold I Saavedra · 2012 to 2026
$23.0M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI PORTER, JAMES T. · 2020 to 2024
$17.7M
CPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI EVANS, WILLIAM E · 2015 to 2019
$15.1M
MOLECULAR PATHOPHYSIOLOGY OF THYROID CELL GROWTHR01CA050706 · NCI · UNIVERSITY OF CINCINNATI · PI FAGIN, JAMES A · 1995 to 2023
$7.5M
Validation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (Study)R01CA154823 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, ALISON P · 2011 to 2020
$5.7M
NCI NIH HHS K01 CA211965NCI NIH HHS K22 CA109351NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA051008NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA050706NCI NIH HHS R01 CA100967NCI NIH HHS R01 CA154823NCI NIH HHS R01 CA184585NCI NIH HHS R01 CA204797NCI NIH HHS R01 CA206010NCI NIH HHS R01 CA228357NCI NIH HHS R01 CA238087NCI NIH HHS R01 CA259396NCI NIH HHS R21 CA199631NCI NIH HHS R21 CA210237NCI NIH HHS U01 CA164974NCI NIH HHS U54 CA163068NCI NIH HHS U54 CA163071NIGMS NIH HHS P30 GM114732NIGMS NIH HHS P50 GM115279NIGMS NIH HHS SC1 GM127276NIGMS NIH HHS U54 GM104940NIGMS NIH HHS U54 GM133807NIMHD NIH HHS L60 MD002419NIMHD NIH HHS L60 MD011128NIMHD NIH HHS U54 MD007587
6 · The paper itself

Abstract

There are well-established disparities in cancer incidence and outcomes by race/ethnicity that result from the interplay between structural, socioeconomic, socio-environmental, behavioural and biological factors. However, large research studies designed to investigate factors contributing to cancer aetiology and progression have mainly focused on populations of European origin. The limitations in clinicopathological and genetic data, as well as the reduced availability of biospecimens from diverse populations, contribute to the knowledge gap and have the potential to widen cancer health disparities. In this review, we summarise reported disparities and associated factors in the United States of America (USA) for the most common cancers (breast, prostate, lung and colon), and for a subset of other cancers that highlight the complexity of disparities (gastric, liver, pancreas and leukaemia). We focus on populations commonly identified and referred to as racial/ethnic minorities in the USA-African Americans/Blacks, American Indians and Alaska Natives, Asians, Native Hawaiians/other Pacific Islanders and Hispanics/Latinos. We conclude that even though substantial progress has been made in understanding the factors underlying cancer health disparities, marked inequities persist. Additional efforts are needed to include participants from diverse populations in the research of cancer aetiology, biology and treatment. Furthermore, to eliminate cancer health disparities, it will be necessary to facilitate access to, and utilisation of, health services to all individuals, and to address structural inequities, including racism, that disproportionally affect racial/ethnic minorities in the USA.

Indexed as

Health Status DisparitiesEthnicityFemaleHumansMaleMinority GroupsNeoplasmsUnited States

Identifiers

PMID32901135
PMCPMC7852513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.