ReviewNature reviews. Gastroenterology & hepatology2020
Sex matters: impact on pathogenesis, presentation and treatment of inflammatory bowel disease.
Review in Nature reviews. Gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 150 citations in OpenAlex.
- Adherence to biologics in patients with inflammatory bowel disease: a systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Sex-related differences in profiles and clinical outcomes of Inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- The Epidemiology of Inflammatory Bowel Disease in Oceania: A Systematic Review and Meta-Analysis of Incidence and Prevalence.Inflammatory bowel diseases · 2024Pooled it
- Impact of sex and socioeconomic status on the likelihood of surgery, hospitalization, and use of medications in inflammatory bowel disease: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Type 2 diabetes and inflammatory bowel disease: a bidirectional two-sample Mendelian randomization study.Scientific reports · 2024Pooled it
- Sex modulates the long-term effects of delivery mode on microbiota-gut barrier crosstalk and colitis susceptibility in mice.Gut microbes · 2026Article
- The burden of anemia related to inflammatory bowel disease in China: Epidemic trends, subtype differences and driving factors.Journal of translational autoimmunity · 2026Article
- Disease burden of inflammatory bowel disease and subtypes in older adults in 172 high- and middle-income countries: Trends from 2000 to 2023 and projections to 2040.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- Association of Dietary Components and Combined Dietary Profiles with Ulcerative Colitis: A Case-Control Study.Diseases (Basel, Switzerland) · 2026Article
- Epidemiology and Treatment of Inflammatory Bowel Disease in Pregnancy: Results from a Retrospective, Observational Study.Digestive diseases and sciences · 2026Observational
- Estrogen impacts NOD2-dependent regulation of intestinal homeostasis.PLoS biology · 2026Article
- Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects.Nature biomedical engineering · 2026Article
- No impact of sex or testosterone treatment on wheel running in a rat model of inflammatory bowel disease.Biology of sex differences · 2026Article
- A Real-World Longitudinal Case-Study Implementing Digital Screening and Treatment for Distress in Inflammatory Bowel Disease: The COMPASS-IBD Patient Journey.Inflammatory bowel diseases · 2026Article
- Drug-associated inflammatory bowel disease: a real-world pharmacovigilance study using the FAERS and JADER databases.Frontiers in immunology · 2026Article
- Inflammatory bowel disease and prostate cancer: from epidemiological controversy to mechanistic hypotheses.Frontiers in immunology · 2026Review
- Prim-O-glucosylcimifugin ameliorates DSS-induced ulcerative colitis via suppressing NLRP3 inflammasome activation.Frontiers in pharmacology · 2026Article
- Multiomics integration of single-cell transcriptomics and bulk sequencing data identifies key biomarkers and predictive models for IBD subtype classification.Frontiers in medicine · 2026Article
- Male predominance in inflammatory bowel disease despite similar disease activity: A large retrospective cohort study.Medicine · 2025Observational
- A large-scale comparison of clinical outcomes to IBD therapies in White and South Asian ethnicities.EClinicalMedicine · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Inflammatory bowel disease (IBD), as do most chronic inflammatory disorders, displays unique features and confers different risk factors in male and female patients. Importantly, sex-based differences in IBD exist for epidemiological incidence and prevalence among different age groups, with men and women developing distinct clinical symptoms and disparity in severity of disease. In addition, the presentation of comorbidities in IBD displays strong sex differences. Notably, particular issues exclusive to women's health, including pregnancy and childbirth, require specific considerations in female patients with IBD of childbearing age that can have a substantial influence on clinical outcomes. This Review summarizes the latest findings regarding sex-based differences in the epidemiology, clinical course, comorbidities and response to current therapies in patients with IBD. Importantly, the latest basic science discoveries in this area of investigation are evaluated to provide insight into potential mechanisms underlying the influence of sex on disease pathogenesis, as well as to design more personalized and efficacious care, in patients with IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.