ArticleNature communications2020
Wrapping glia regulates neuronal signaling speed and precision in the peripheral nervous system of Drosophila.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Written in the Stars: Astrocyte Biology From Evolution to Disease.Acta physiologica (Oxford, England) · 2026Review
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- Peroxisomal import is circadian in glia and regulates sleep and lipid metabolism.PLoS biology · 2026Article
- Drosophila view on glia in peripheral sensory neuropathy.Neural regeneration research · 2026Article
- Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids.bioRxiv : the preprint server for biology · 2026Article
- Neural bottlenecks: axon count, distribution, and conduction in the Manduca sexta neck connective.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- TheeLife · 2026Article
- Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at theeLife · 2025Article
- Invertebrate glial barriers as a model for understanding blood-brain barrier evolution.Fluids and barriers of the CNS · 2025Review
- Wings of Discovery: UsingCells · 2025Review
- Many faces of neuronal activity manipulation in Drosophila.Neural regeneration research · 2025Article
- Cholinergic and Glutamatergic Axons Differentially Require Glial Support in the Drosophila PNS.Glia · 2025Article
- Article
- Glia phagocytose neuronal sphingolipids to infiltrate developing synapses.bioRxiv : the preprint server for biology · 2025Article
- Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions.Scientific reports · 2025Article
- Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking.bioRxiv : the preprint server for biology · 2025Article
- Synthetic control removes spurious discoveries from double dipping in single-cell and spatial transcriptomics data analyses.bioRxiv : the preprint server for biology · 2024Article
- Article
- Glia as Functional Barriers and Signaling Intermediaries.Cold Spring Harbor perspectives in biology · 2024Review
- TheFrontiers in cellular neuroscience · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functionality of the nervous system requires transmission of information along axons with high speed and precision. Conductance velocity depends on axonal diameter whereas signaling precision requires a block of electrical crosstalk between axons, known as ephaptic coupling. Here, we use the peripheral nervous system of Drosophila larvae to determine how glia regulates axonal properties. We show that wrapping glial differentiation depends on gap junctions and FGF-signaling. Abnormal glial differentiation affects axonal diameter and conductance velocity and causes mild behavioral phenotypes that can be rescued by a sphingosine-rich diet. Ablation of wrapping glia does not further impair axonal diameter and conductance velocity but causes a prominent locomotion phenotype that cannot be rescued by sphingosine. Moreover, optogenetically evoked locomotor patterns do not depend on conductance speed but require the presence of wrapping glial processes. In conclusion, our data indicate that wrapping glia modulates both speed and precision of neuronal signaling.
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