Evidence map›Paper›PMID 32901021›Full record

ArticleNature communications2020

Engineering multiple species-like genetic incompatibilities in insects.

Maciej Maselko, Nathan Feltman, Ambuj Upadhyay, Amanda Hayward, Siba Das, Nathan Myslicki, Aidan J Peterson, Michael B O'Connor, Michael J Smanski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 74 citations in OpenAlex.

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  18. Speciation and adaptation research meets genome editing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Maciej Maselko *Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Nathan Feltman *Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Ambuj UpadhyayDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Amanda HaywardDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Siba DasDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Nathan MyslickiDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA.
Aidan J PetersonDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Saint Paul, MN, 55108, USA.ORCID http://orcid.org/0000-0002-6801-3364
Michael B O'ConnorDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Saint Paul, MN, 55108, USA.
Michael J SmanskiDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN, USA. smanski@umn.edu.ORCID http://orcid.org/0000-0002-6029-8326
University of Minnesota · US

Funding

Inter-organ signals regulating metabolism, physiology and developmental timingR35GM118029 · NIGMS · UNIVERSITY OF MINNESOTA · PI O'CONNOR, MICHAEL BRENDAN · 2016 to 2025
$3.8M
NIGMS NIH HHS R35 GM118029
6 · The paper itself

Abstract

Speciation constrains the flow of genetic information between populations of sexually reproducing organisms. Gaining control over mechanisms of speciation would enable new strategies to manage wild populations of disease vectors, agricultural pests, and invasive species. Additionally, such control would provide safe biocontainment of transgenes and gene drives. Here, we demonstrate a general approach to create engineered genetic incompatibilities (EGIs) in the model insect Drosophila melanogaster. EGI couples a dominant lethal transgene with a recessive resistance allele. Strains homozygous for both elements are fertile and fecund when they mate with similarly engineered strains, but incompatible with wild-type strains that lack resistant alleles. EGI genotypes can also be tuned to cause hybrid lethality at different developmental life-stages. Further, we demonstrate that multiple orthogonal EGI strains of D. melanogaster can be engineered to be mutually incompatible with wild-type and with each other. EGI is a simple and robust approach in multiple sexually reproducing organisms.

Indexed as

Genetic SpeciationAnimalsAnimals, Genetically ModifiedCrosses, GeneticDrosophila melanogasterFemaleGenes, InsectGenes, LethalGenetic EngineeringGenotypeHybridization, GeneticMaleModels, GeneticTransgenes

Identifiers

PMID32901021
PMCPMC7478965
OpenAlexW3083897097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.