ArticleNature communications2020
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 663 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
663citing papers in PubMed, 1 pooled it
37.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
663 citing papers in PubMed, 1 synthesis or guideline pooled it, 973 citations in OpenAlex.
- The role of natural products in the intestinal barrier: a bibliometric analysis from 2004 to 2025.Frontiers in immunology · 2026Pooled it
- Baseline gut microbiome and metabolome profiles predict weight loss after a structured lifestyle intervention.Microbiome · 2026Trial
- Management of symptomatic uncomplicated diverticular disease (SUDD) of the colon with Clostridium butyricum CBM588 versus rifaximin: a retrospective cross-sectional study.International journal of colorectal disease · 2025Trial
- Synthetic microbial communities: emerging live biotherapeutics for targeted gut microbiome modulation.Gut microbes · 2026Review
- High dietary BGut microbes · 2026Article
- Targeting the gut-bone axis in osteoporosis: probiotic interventions and other microbiota-based therapeutic strategies.Gut microbes · 2026Review
- Gut-lung axis and microbiome alterations in mycobacterial infections: from pathogenesis to therapeutic potential.Gut microbes · 2026Review
- Article
- Effects of maternal supplementation with fatty acid-balanced oil on the performance of sows and intestinal barrier function of offspring.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- The gut microbiota-tryptophan metabolism-immune axis in inflammatory bowel disease: Mechanisms and therapeutic prospects.Human vaccines & immunotherapeutics · 2026Review
- Dynamic feedback BacGuard anchors microbial metabolism to host symbiosis in real-time ulcerative colitis therapy.Bioactive materials · 2026Article
- ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review).International journal of molecular medicine · 2026Review
- The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications.Current microbiology · 2026Review
- Multi-omics insights into growth impairment mechanisms in children with persistent diarrhea.Microbiology spectrum · 2026Article
- Fecal Microbiota Transplantation and Microbiota-Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions.Clinical pharmacology and therapeutics · 2026Review
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- IL-22 increases proglucagon-expressing enteroendocrine cells via STAT3 in human iPSC-derived intestinal epithelium.Endocrinology · 2026Article
- Elevated microbially-derived metabolites in autism: a possible diagnostic screening test for a distinct ASD phenotype.Molecular psychiatry · 2026Article
- Effects of Hedan Tablets Combined With Simvastatin on Hyperlipidemia: Insights From Microbiomics and Metabolomics.Biomedical chromatography : BMC · 2026Article
- Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review).Molecular medicine reports · 2026Review
603 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Wenjing YangDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Tianming YuDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Xiangsheng HuangDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Anthony J BilottaDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Leiqi XuDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Yao LuDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jiaren SunDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Fan PanImmunology and Hematopoiesis Division, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Jia ZhouChemical Biology Program, Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.ORCID http://orcid.org/0000-0002-2811-1090
Wenbo ZhangDepartment of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Suxia YaoDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Craig L MaynardDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID http://orcid.org/0000-0001-5876-8168
Nagendra SinghDepartment of Biochemistry and Molecular Biology, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.ORCID http://orcid.org/0000-0003-2540-6990
Sara M DannDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, 77555, USA.ORCID http://orcid.org/0000-0002-6893-2838
Zhanju LiuDepartment of Gastroenterology, The Shanghai Tenth People's Hospital, 200072, Shanghai, China.ORCID http://orcid.org/0000-0002-0326-543X
Yingzi CongDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, 77555, USA. yicong@utmb.edu.ORCID http://orcid.org/0000-0003-4167-7395
The University of Texas Medical Branch at Galveston · USShanghai Tenth People's Hospital · CNAugusta University Health · USJohns Hopkins University · USUniversity of Alabama at Birmingham · US
Funding
Th17-IgA Axis in Regulation of Intestinal InflammationR01DK105585 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2016 to 2020
$1.8MGPR120 regulation of inflammatory bowel diseaseR01DK125011 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2022
$1.5MMicrobiota metabolites, GPR, and inflammatory bowel diseasesR01DK112436 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2017 to 2020
$1.4MNIDDK NIH HHS R01 DK105585NIDDK NIH HHS R01 DK112436NIDDK NIH HHS R01 DK125011
Abstract
Innate lymphoid cells (ILCs) and CD4
Indexed as
Immunity, InnateAnimalsButyratesCD4-Positive T-LymphocytesCitrobacter rodentiumColitisEnterobacteriaceae InfectionsFatty Acids, VolatileGastrointestinal MicrobiomeHistone Deacetylase InhibitorsHumansHypoxia-Inducible Factor 1, alpha SubunitInterleukin-22InterleukinsIn Vitro TechniquesLymphocytesButyratesFatty Acids, VolatileFFAR3 protein, humanHIF1A protein, humanHistone Deacetylase InhibitorsHypoxia-Inducible Factor 1, alpha SubunitInterleukin-22InterleukinsReceptors, Aryl HydrocarbonReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.