ArticleProceedings of the National Academy of Sciences of the United States of America2020
Spatiotemporal dissociation of fMRI activity in the caudate nucleus underlies human de novo motor skill learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Distinct Roles of Directional and Positional Experience in De Novo Visuomotor Learning.eNeuro · 2026Article
- Brain-inspired strategies for efficient artificial intelligence.Molecules and cells · 2026Review
- Striatal Dopamine Transporter and Rest Tremor in Parkinson Disease: A Clinical Validation.Neurology · 2026Observational
- Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Association of blood pressure variability with white matter hyperintensities and nigrostriatal dopaminergic deficits in drug-naïve Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Transcutaneous vagus nerve stimulation reduces total striatal GABA+ content, increases DLPFC Glu content, and facilitates early-phase motor learning.Frontiers in human neuroscience · 2026Article
- Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex.iScience · 2025Article
- Principal axis of primate basal ganglia in processing cognitive flexibility and habitual stability.Brain : a journal of neurology · 2025Review
- Does enhanced expectancy mitigate the negative impact of gender stereotype threat on women's motor learning, perceived competence and self-efficacy?BMC psychology · 2025Article
- Sense of agency for a new motor skill emerges via the formation of a structural internal model.Communications psychology · 2025Article
- Effective Motor Skill Learning Induces Inverted-U Load-Dependent Activation in Contralateral Pre-Motor and Supplementary Motor Area.Human brain mapping · 2025Article
- Brain networks and intelligence: A graph neural network based approach to resting state fMRI data.Medical image analysis · 2025Article
- Emergence of Categorical Representations in Parietal and Ventromedial Prefrontal Cortex across Extended Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Motivational control of habits: A preregistered fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain Networks and Intelligence: A Graph Neural Network Based Approach to Resting State fMRI Data.ArXiv · 2024Article
- Early-life risperidone alters locomotor responses to apomorphine and quinpirole in adulthood.Behavioural brain research · 2024Article
- Double dissociation of visuomotor interaction mediated by visual feedback during continuous de novo motor learning.Communications biology · 2024Article
- Corticostriatal activity related to performance during continuous de novo motor learning.Scientific reports · 2024Article
- Motor learning is modulated by dopamine availability in the sensorimotor putamen.Brain communications · 2024Article
- Anatomical and Functional Comparison of the Caudate Tail in Primates and the Tail of the Striatum in Rodents: Implications for Sensory Information Processing and Habitual Behavior.Molecules and cells · 2023Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor skill learning involves a complex process of generating novel movement patterns guided by evaluative feedback, such as a reward. Previous literature has suggested anteroposteriorly separated circuits in the striatum to be implicated in early goal-directed and later automatic stages of motor skill learning, respectively. However, the involvement of these circuits has not been well elucidated in human de novo motor skill learning, which requires learning arbitrary action-outcome associations and value-based action selection. To investigate this issue, we conducted a human functional MRI (fMRI) experiment in which participants learned to control a computer cursor by manipulating their right fingers. We discovered a double dissociation of fMRI activity in the anterior and posterior caudate nucleus, which was associated with performance in the early and late learning stages. Moreover, cognitive and sensorimotor cortico-caudate interactions predicted individual learning performance. Our results suggest parallel cortico-caudate networks operating in different stages of human de novo motor skill learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.