Evidence map›Paper›PMID 32900885›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2020

Nutritional Modulation of the Microbiome and Immune Response.

Ansen H P Burr, Amrita Bhattacharjee, Timothy W Hand

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  7. Article
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  9. Review
  10. Article
  11. Review
  12. Engineering Strategies to Modulate the Gut Microbiome and Immune System.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  13. Review
  14. Neural crest cells as a source of microevolutionary variation.Seminars in cell & developmental biology · 2023
    Review
  15. Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ansen H P BurrRichard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224; and.
Amrita BhattacharjeeRichard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224; and.
Timothy W HandRichard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224; and timothy.hand@chp.edu.ORCID 0000-0002-2684-9462
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · US

Funding

Autoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6M
Defining the role of the mucosal immune response and microbiota in enteropathy-driven oral vaccine failureR21AI142051 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAND, TIMOTHY WESLEY · 2019 to 2020
$412k
NIAID NIH HHS R21 AI142051NIAID NIH HHS T32 AI089443
6 · The paper itself

Abstract

The evolution of the immune system, diet, and the microbiome are interconnected. Dietary metabolites modulate the cells of the immune system both directly and indirectly via shifts in the composition of the intestinal microbiota and its products. As a result, overconsumption and malnutrition can have substantial effects on immune responses and inflammation. In resource-rich nations, diets high in processed foods, fat, and sugar can contribute to chronic inflammatory conditions, which are on the rise worldwide. Conversely, in resource-poor countries, malnutrition associated with food insecurity can lead to immunodeficiencies and shifts in the microbiome that drive intestinal inflammation. Developing a deeper understanding of the relationship between diet, microbiota, and the immune system is of huge importance, given its impact on inflammatory diseases and its potential as an easily modifiable mediator of immunomodulation.

Indexed as

AnimalsDietDiet TherapyGastrointestinal MicrobiomeHumansImmune SystemImmunityImmunomodulationInflammationNutritional Physiological Phenomena

Identifiers

PMID32900885
PMCPMC7490768
OpenAlexW3083965422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.