Evidence map›Paper›PMID 32900815›Full record

ArticleInfection and immunity2020

Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene Expression.

Alexandra E Chirakos, Kathleen R Nicholson, Allison Huffman, Patricia A Champion

Abstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Tyloxapol inhibits ESX-1 secretion inJournal of bacteriology · 2026
    Article
  4. PDIM/PGL-deficientMicrobiology resource announcements · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Journal of bacteriology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra E ChirakosEck Institute for Global Health, Boler-Parsegian Center for Rare and Neglected Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Kathleen R NicholsonEck Institute for Global Health, Boler-Parsegian Center for Rare and Neglected Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Allison HuffmanEck Institute for Global Health, Boler-Parsegian Center for Rare and Neglected Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Patricia A ChampionEck Institute for Global Health, Boler-Parsegian Center for Rare and Neglected Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA pchampio@nd.edu.ORCID 0000-0002-6733-596X

Funding

Role of N-alpha acetylation in mycobacterial secretion and virulenceR01AI106872 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2013 to 2024
$4.2M
Exploration of the genetic interaction between secreted virulence determinants from pathogenic mycobacteriaR21AI142127 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2019 to 2020
$425k
Mechanisms of ESX-1-dependent Gene Expression in Pathogenic MycobacteriaR21AI149235 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2020 to 2021
$425k
NIAID NIH HHS R01 AI106872NIAID NIH HHS R21 AI142127NIAID NIH HHS R21 AI149235
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntigens, BacterialBacterial ProteinsGene Expression Regulation, BacterialMacrophagesMiceMycobacterium marinumRAW 264.7 CellsTranscription FactorsType VII Secretion SystemsVirulence FactorsAntigens, BacterialBacterial ProteinsESAT-6 protein, Mycobacterium tuberculosisTranscription FactorsType VII Secretion SystemsVirulence FactorsESAT-6ESX-1mycobacterial pathogenesisMycobacterium marinumprotein secretiontype VIIWhiB6

Identifiers

PMID32900815
PMCPMC7671884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.