Evidence map›Paper›PMID 32900781›Full record

ArticleBMJ open respiratory research2020

Characteristics and outcomes of admitted patients infected with SARS-CoV-2 in Uganda.

Bruce Kirenga, Winters Muttamba, Alex Kayongo, Christopher Nsereko, Trishul Siddharthan, John Lusiba, Levicatus Mugenyi, Rosemary K Byanyima, William Worodria, Fred Nakwagala and 18 more

Abstract read
In one paragraph

Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Bruce KirengaLung Institute, Makerere University, Kampala, Uganda brucekirenga@yahoo.co.uk.ORCID http://orcid.org/0000-0002-2023-2840
Winters MuttambaLung Institute, Makerere University, Kampala, Uganda.
Alex KayongoLung Institute, Makerere University, Kampala, Uganda.
Christopher NserekoDpartment of Medicine, Entebbe Regional Referral Hospital, Entebbe, Uganda.
Trishul SiddharthanPulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, USA.
John LusibaUganda Peoples Defense Forces, Uganda Heart Institute Ltd, Kampala, Uganda.
Levicatus MugenyiLung Institute, Makerere University, Kampala, Uganda.
Rosemary K ByanyimaDepartment of Radiology, Mulago National Specialised Hospital, Kampala, Uganda.
William WorodriaUganda Ministry of Health, Kampala, Uganda.
Fred NakwagalaDepartment of Medicine, Mulago National Specialised Hospital, Kampala, Uganda.
Rebecca NantandaLung Institute, Makerere University, Kampala, Uganda.
Ivan KimuliLung Institute, Makerere University, Kampala, Uganda.
Winceslaus KatagiraLung Institute, Makerere University, Kampala, Uganda.
Bernard Sentalo BagayaDepartment of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda.
Emmanuel NasingheDepartment of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda.
Hellen Aanyu-TukamuhebwaDepartment of Paediatrics, Mulago National Specialised Hospital, Kampala, Uganda.
Beatrice AmugeDepartment of Nursing, Mulago National Specialised Hospital, Kampala, Uganda.
Rogers SekibiraLung Institute, Makerere University, Kampala, Uganda.
Esther BuregyeyaSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Noah KiwanukaSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Moses MuwangaDepartment of Medicine, Entebbe Regional Referral Hospital, Entebbe, Uganda.
Samuel KalungiPathology, Makerere University College of Health Sciences, Kampala, Uganda.
Moses Lutaakome JolobaDepartment of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda.
David Patrick KateeteDepartment of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda.
Baterana ByarugabaDepartment of Medicine, Mulago National Specialised Hospital, Kampala, Uganda.
Moses R KamyaMedicine, Makerere University College of Health Sciences, Kampala, Uganda.
Henry MwebesaRepublic of Uganda Ministry of Health, Kampala, Uganda.
William BazeyoEntebbe Regional Refferal Hospital, Makerere University, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleDetailed data on the characteristics and outcomes of patients with COVID-19 in sub-Saharan Africa are limited.

objectiveWe determined the clinical characteristics and treatment outcomes of patients diagnosed with COVID-19 in Uganda. MEASUREMENTS: As of the 16 May 2020, a total of 203 cases had been confirmed. We report on the first 56 patients; 29 received hydroxychloroquine (HCQ) and 27 did not. Endpoints included admission to intensive care, mechanical ventilation or death during hospitalisation. MAIN

resultsThe median age was 34.2 years; 67.9% were male; and 14.6% were <18 years. Up 57.1% of the patients were asymptomatic. The most common symptoms were fever (21.4%), cough (19.6%), rhinorrhea (16.1%), headache (12.5%), muscle ache (7.1%) and fatigue (7.1%). Rates of comorbidities were 10.7% (pre-existing hypertension), 10.7% (diabetes) and 7.1% (HIV), Body Mass Index (BMI) of ≥30 36.6%. 37.0% had a blood pressure (BP) of >130/90 mm Hg, and 27.8% had BP of >140/90 mm Hg. Laboratory derangements were leucopenia (10.6%), lymphopenia (11.1%) and thrombocytopenia (26.3%). Abnormal chest X-ray was observed in 14.3%. No patients reached the primary endpoint. Time to clinical recovery was shorter among patients who received HCQ, but this difference did not reach statistical significance.

conclusionMost of the patients with COVID-19 presented with mild disease and exhibited a clinical trajectory not similar to other countries. Outcomes did not differ by HCQ treatment status in line with other concluded studies on the benefit of using HCQ in the treatment of COVID-19.

Indexed as

BetacoronavirusAdultAge FactorsBody Mass IndexCohort StudiesCoronavirus InfectionsCOVID-19Enzyme InhibitorsFemaleHospitalizationHospital MortalityHumansHydroxychloroquineMaleMiddle AgedPandemicsEnzyme InhibitorsHydroxychloroquineclinical epidemiologyrespiratory infectionviral infection

Identifiers

PMID32900781
PMCPMC7477797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.