Evidence map›Paper›PMID 32900682›Full record

ArticleAntimicrobial agents and chemotherapy2020

Building Optimal Three-Drug Combination Chemotherapy Regimens.

G L Drusano, Michael N Neely, Sarah Kim, Walter M Yamada, Stephan Schmidt, Brandon Duncanson, Jocelyn Nole, Nino Mtchedlidze, Charles A Peloquin, Arnold Louie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. A Case Report from Somalia: Multispecies Intestinal Parasitism andInternational medical case reports journal · 2025
    Article
  3. Article
  4. Article
  5. Delamanid or pretomanid? A Solomonic judgement!The Journal of antimicrobial chemotherapy · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

G L DrusanoInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA gdrusano@ufl.edu.
Michael N NeelyDivision of Pediatric Infectious Diseases, Children's Hospital of Los Angeles, Los Angeles, California, USA.
Sarah KimCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.ORCID 0000-0002-9179-0735
Walter M YamadaDivision of Pediatric Infectious Diseases, Children's Hospital of Los Angeles, Los Angeles, California, USA.
Stephan SchmidtCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Brandon DuncansonInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Jocelyn NoleInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Nino MtchedlidzeInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.
Charles A PeloquinDivision Head for the Translational Research Division, Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-9002-7052
Arnold LouieInstitute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA.

Funding

Optimizing Combination Therapy to Accelerate Clinical Cure of TuberculosisP01AI123036 · NIAID · UNIVERSITY OF FLORIDA · PI DRUSANO, GEORGE LOUIS · 2016 to 2020
$12.0M
Rapid Identification of Optimal Combination Regimens for Pseudomonas aeruginosaR01AI121430 · NIAID · UNIVERSITY OF FLORIDA · PI DRUSANO, GEORGE LOUIS, LOUIE, ARNOLD · 2016 to 2020
$4.1M
NIAID NIH HHS P01 AI123036NIAID NIH HHS R01 AI121430
6 · The paper itself

Abstract

Multidrug therapy is often required. Examples include antiviral therapy, nosocomial infections, and, most commonly, anti-

Indexed as

Mycobacterium tuberculosisPharmaceutical PreparationsAntitubercular AgentsDrug Therapy, CombinationLeprostatic AgentsAntitubercular AgentsLeprostatic AgentsPharmaceutical Preparationscombination therapymathematical modelingMonte Carlo simulation

Identifiers

PMID32900682
PMCPMC7577121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.