Evidence map›Paper›PMID 32900518›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2021

Malnutrition and nutritional therapy in patients with SARS-CoV-2 disease.

Loris Pironi, Anna Simona Sasdelli, Federico Ravaioli, Bianca Baracco, Claudia Battaiola, Giulia Bocedi, Lucia Brodosi, Laura Leoni, Giulia Aurora Mari, Alessandra Musio

Registry-linked trialAbstract read
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06727474 (Evolution of Quality of Life, Functional Capacity, Nutritional Status and Return to Work Activity in Patients Admitted for Severe Pneumonia Due to COVID 19 Requiring Invasive Mechanical Ventilation), which is not on this map. Cited by 80 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06727474 completednot on this map

Evolution of Quality of Life, Functional Capacity, Nutritional Status and Return to Work Activity in Patients Admitted for Severe Pneumonia Due to COVID 19 Requiring Invasive Mechanical Ventilation

TypeobservationalSponsorHospital Nacional Profesor Alejandro PosadasRan2020 to 2021Enrolled51ConditionsPost-intensive Care Syndrome, COVID-19ArmsHealth-Related Quality of Life (HRQoL) with EQ-5D-3L
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  7. Global Leadership Initiative on Malnutrition as a predictor of mortality and prolonged hospitalization in emergency department patients: A prospective cohort study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Loris PironiClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. Electronic address: loris.pironi@unibo.it.
Anna Simona SasdelliClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Federico RavaioliClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Bianca BaraccoClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Claudia BattaiolaClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Giulia BocediClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Lucia BrodosiClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Laura LeoniClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Giulia Aurora MariClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Alessandra MusioClinical Nutrition and Metabolism Unit and Center for Chronic Intestinal Failure, Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThe prevalence of malnutrition and the provided nutritional therapy were evaluated in all the patients with SARS-CoV-2 infection (COVID-19) hospitalized in a 3rd level hospital in Italy.

methodsA one-day audit was carried out recording: age, measured or estimated body weight (BW) and height, body mass index (BMI, kg/m

resultsA total of 268 patients was evaluated; intermediate care units (IMCUs, 61%), sub-intensive care units (SICUs, 8%), intensive care units (ICUs, 17%) and rehabilitation units (RUs, 14%): BMI: <18.5, 9% (higher in RUs, p = 0.008) and ≥30, 13% (higher in ICUs, p = 0.012); WL ≥ 5%, 52% (higher in ICUs and RUs, p = 0.001); CRP >0.5: 78% (higher in ICUs and lower in RUs, p < 0.001); Nutritional risk and malnutrition were present in 77% (higher in ICUs and RUs, p < 0.001) and 50% (higher in ICUs, p = 0.0792) of the patients, respectively. HD intake ≤50%, 39% (higher in IMCUs and ICUs, p < 0.001); ONS, EN and PN were prescribed to 6%, 13% and 5%, respectively. Median energy and protein intake/kg BW were 25 kcal and 1.1 g (both lower in ICUs, p < 0.05) respectively.

conclusionsMost of the patients were at nutritional risk, and one-half of them was malnourished. The frequency of nutritional risk, malnutrition, disease/inflammation burden and decrease intake of HD differed among the intensity of care settings, where the patients were managed according to the severity of the disease. The patient energy and protein intake were at the lowest limit or below the recommended amounts, indicating the need for actions to improve the nutritional care practice.

Indexed as

AgedAged, 80 and overComorbidityCOVID-19C-Reactive ProteinCross-Sectional StudiesDietary ProteinsEnergy IntakeFemaleHospitalizationHumansIntensive Care UnitsItalyMaleMalnutritionMiddle AgedC-Reactive ProteinDietary ProteinsCOVID-19GLIMMalnutritionNRS-2002Nutritional therapySARS-CoV-2

Identifiers

PMID32900518
PMCPMC7450234

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.