Evidence map›Paper›PMID 32900308›Full record

ArticleProceedings. Biological sciences2020

Cellular bicarbonate accumulation and vesicular proton transport promote calcification in the sea urchin larva.

Marian Y Hu, Inga Petersen, William Weijen Chang, Christine Blurton, Meike Stumpp

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Possible role of microtubules in vesicular transport of matrix protein during sea urchin larval biomineralization.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  3. Co-option of Lysosomal Machinery for Sponge Biosilicification.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Proteomic characterization of a foraminiferal test's organic matrix.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Extracellular carbonic anhydrase activity promotes a carbon concentration mechanism in metazoan calcifying cells.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marian Y HuInstitute of Physiology, Christian-Albrechts-University Kiel, Hermann-Rodewaldstraße 5, 24118 Kiel, Germany.
Inga PetersenInstitute of Physiology, Christian-Albrechts-University Kiel, Hermann-Rodewaldstraße 5, 24118 Kiel, Germany.
William Weijen ChangInstitute of Physiology, Christian-Albrechts-University Kiel, Hermann-Rodewaldstraße 5, 24118 Kiel, Germany.
Christine BlurtonInstitute of Immunobiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Meike StumppInstitute of Immunobiology, Christian-Albrechts-University Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sea urchin embryo develops a calcitic endoskeleton through intracellular formation of amorphous calcium carbonate (ACC). Intracellular precipitation of ACC, requires [Formula: see text] concentrating as well as proton export mechanisms to promote calcification. These processes are of fundamental importance in biological mineralization, but remain largely unexplored. Here, we demonstrate that the calcifying primary mesenchyme cells (PMCs) use Na

Indexed as

AnimalsBicarbonatesBiological TransportCalcification, PhysiologicCalcium CarbonateHydrogen-Ion ConcentrationOceans and SeasProtonsSea UrchinsSeawaterBicarbonatesCalcium CarbonateProtonsbiomineralizationintracellular pHlife-cell imagingocean acidificationprimary mesenchyme cellsvesicular pH

Identifiers

PMID32900308
PMCPMC7542784
OpenAlexW3084226250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.