Evidence map›Paper›PMID 32899967›Full record

ArticleBrain sciences2020

The Effects of Hypocapnia on Brain Tissue Pulsations.

Meshal Alharbi, Poppy Turner, Jonathan Ince, Mitsuhiro Oura, Kelechi U Ebirim, Alanoud Almudayni, Andrea Lecchini-Visintini, Jatinder S Minhas, Emma M L Chung

Abstract read
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meshal AlharbiCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.
Poppy TurnerCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.
Jonathan InceCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.
Mitsuhiro OuraNihon Kohden Corporation, Tokorozawa-shi, Saitama 359-0037, Japan.
Kelechi U EbirimSchool of Engineering, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0003-2735-8793
Alanoud AlmudayniCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.
Andrea Lecchini-VisintiniSchool of Engineering, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0002-1654-8877
Jatinder S MinhasCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.ORCID 0000-0002-0576-9105
Emma M L ChungCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK.ORCID 0000-0003-3723-9085

Funding

Medical Research Council MC_PC_17171The Dunhill Medical Trust RTF97/0117
6 · The paper itself

Abstract

Hypocapnia is known to affect patients with acute stroke and plays a key role in governing cerebral autoregulation. However, the impact of hypocapnia on brain tissue pulsations (BTPs) is relatively unexplored. As BTPs are hypothesised to result from cerebrovascular resistance to the inflow of pulsatile arterial blood, it has also been hypothesised that cerebral autoregulation changes mediated by hypocapnia will alter BTP amplitude. This healthy volunteer study reports measurements of BTPs obtained using transcranial tissue Doppler (TCTD). Thirty participants underwent hyperventilation to induce mild hypocapnia. BTP amplitude, EtCO

Indexed as

brain tissue pulsationsBTPcerebral autoregulationhypocapnia

Identifiers

PMID32899967
PMCPMC7565182

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.