Evidence map›Paper›PMID 32899914›Full record

ArticleBiomedicines2020

Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells.

Nosheen Akhtar, Muhammad Waleed Baig, Ihsan-Ul Haq, Vinothini Rajeeve, Pedro Rodriguez Cutillas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nosheen AkhtarCell Signalling and Proteomics Group, Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Muhammad Waleed BaigDepartment of Pharmacy, Quaid-e-Azam University, Islamabad 45320, Pakistan.
Ihsan-Ul HaqDepartment of Pharmacy, Quaid-e-Azam University, Islamabad 45320, Pakistan.
Vinothini RajeeveCell Signalling and Proteomics Group, Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Pedro Rodriguez CutillasCell Signalling and Proteomics Group, Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0002-3426-2274
Queen Mary University of London · GBQuaid-i-Azam University · PK

Funding

Biotechnology and Biological Sciences Research Council BB/M006174/1
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease. Withanolides, a group of steroidal lactones found in Solanaceae plants are of potential interest due to their reported anticancer activities in different settings. In this study we investigated the anti-proliferative effects and mode of action of Solanaceae-derived withanolides in AML cell models; these metabolites include withametelin (WTH) and Coagulansin A (CoA) isolated from

Indexed as

acute myeloid leukemiaapoptosiscoagulansin AMAPK pathwayPI3K pathwayproteomicswithametelin

Identifiers

PMID32899914
PMCPMC7555989
OpenAlexW3083081149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.