ArticleJournal of clinical medicine2020
Late Diagnosis of Infants with PCD and Neonatal Respiratory Distress.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03517865 (International Primary Ciliary Dyskinesia Cohort), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
International Primary Ciliary Dyskinesia Cohort
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Primary Ciliary Dyskinesia Caused by a Heterozygous Large Deletion in DNAAF11 Accompanied by a Hemizygous Nonsense Variant: A Case Report from Japan.Internal medicine (Tokyo, Japan) · 2026Article
- Situs Ambiguus Is Associated With Adverse Clinical Outcomes in Children With Primary Ciliary Dyskinesia.Chest · 2024Article
- Clinical and Genetic Characterization of Patients with Primary Ciliary Dyskinesia in Southwest Saudi Arabia: A Cross Sectional Study.Children (Basel, Switzerland) · 2023Article
- Sinonasal disease among patients with primary ciliary dyskinesia: an international study.ERJ open research · 2023Article
- Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia.Annals of the American Thoracic Society · 2022Article
- Lung function from school age to adulthood in primary ciliary dyskinesia.The European respiratory journal · 2022Article
- Observational
- Chronic airway disease in primary ciliary dyskinesia-spiced with geno-phenotype associations.American journal of medical genetics. Part C, Seminars in medical genetics · 2022Review
- Clinical phenotypes of primary ciliary dyskinesia.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Impact of Motile Ciliopathies on Human Development and Clinical Consequences in the Newborn.Cells · 2021Review
- COVID-19 Vaccinations: Perceptions and Behaviours in People with Primary Ciliary Dyskinesia.Vaccines · 2021Article
- Special Issue: Rare Respiratory Diseases: A Personal and Public Health Issue.Journal of clinical medicine · 2021Article
- Progress in Diagnosing Primary Ciliary Dyskinesia: The North American Perspective.Diagnostics (Basel, Switzerland) · 2021Review
- Evaluation of a Clinical Index as a Predictive Tool for Primary Ciliary Dyskinesia.Diagnostics (Basel, Switzerland) · 2021Article
- Genetic Testing for Neonatal Respiratory Disease.Children (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
16 authors at 13 institutions in 10 countries.
Funding
Abstract
Neonatal respiratory distress (NRD) is common among infants with primary ciliary dyskinesia (PCD), but we do not know whether affected neonates receive a timely diagnosis. We used data from the international PCD cohort and assessed the proportion of patients with PCD who had a history of NRD and their age at diagnosis, stratifying by presence of laterality defects. First we analyzed data from all participants diagnosed after 2000, followed by individuals from a subgroup diagnosed using stricter criteria. Among the 1375 patients in the study, 45% had a history of NRD and 42% had laterality defects. Out of the 476 children with definite PCD diagnosis, 55% had a history of NRD and 50% had laterality defects. Overall, 30% of children with PCD were diagnosed during the first 12 months of life. This varied from 13% in those with situs solitus and no NRD, to 21% in those with situs solitus and NRD, 33% in those with situs anomalies but no NRD, and 52% in those with both situs anomalies and NRD. Our results suggest that we need to improve our knowledge of the neonatal presentation of infants with PCD and apply it so that these patients will receive appropriate care sooner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.