ArticleBrain sciences2020
Pathophysiology of Swallowing Dysfunction in Parkinson Disease and Lack of Dopaminergic Impact on the Swallow Function and on the Effect of Thickening Agents.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Transdermal delivery of pramipexole dihydrochloride using dissolving polymeric microneedle patches for improved Parkinson's disease management.International journal of pharmaceutics: X · 2026Article
- Characteristics of Swallowing Function in People with Parkinson's Disease: A Scoping Review.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Dysphagia in Huntington's Disease: An Evaluation of Swallowing Disturbance across the HD-ISS Staging Spectrum.Movement disorders clinical practice · 2025Article
- Profiling Swallowing Safety and Physiology in People With Huntington's Disease.Neurogastroenterology and motility · 2025Article
- Approach to Patients with Dysphagia: Clinical Insights.Brain sciences · 2025Article
- Effect of deep brain stimulation on dysphagia in Parkinson's disease: mechanisms, evidence, and outlook.Frontiers in aging neuroscience · 2025Review
- The Effect of Oropharyngeal Resting Tremor on Swallowing Function in a Clinical Cohort of People with Parkinson's Disease.Dysphagia · 2024Article
- Cough Correlates of Functional Swallow Outcomes in Atypical Parkinsonism.Movement disorders clinical practice · 2024Article
- Brain and Pharyngeal Responses Associated with Pharmacological Treatments for Oropharyngeal Dysphagia in Older Patients.Dysphagia · 2023Review
- Differences in pharyngeal swallow event timing: Healthy aging, Parkinson disease, and amyotrophic lateral sclerosis.Laryngoscope investigative otolaryngology · 2023Article
- A narrative review on the role and main findings of the Videofluoroscopic Study of Swallowing in Parkison's disease.La Radiologia medica · 2023Review
- The Frequency of Atypical and Extreme Values for Pharyngeal Phase Swallowing Measures in Mild Parkinson Disease Compared to Healthy Aging.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Impact of Progression of Parkinson's Disease on Swallowing Ability and Oral Environment.Parkinson's disease · 2021Article
- Analysis of Quality of Life and Nutritional Status in Elderly Patients with Dysphagia in Order to Prevent Hospital Admissions in a COVID-19 Pandemic.Life (Basel, Switzerland) · 2020Article
- Physiological Mechanisms and Associated Pathophysiology of Dysphagia in Older Adults.Gerontology & geriatric medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
(1) Background: The effect of dopaminergic treatment on swallowing response in patients with Parkinson's disease (PD) suffering oropharyngeal dysphagia (OD) is not understood. Aim: To characterize OD pathophysiology in PD and to assess whether dopaminergic states affect swallow function and the effect of thickeners. (2) Methods: Fifty patients with PD (40 evaluated in OFF/ON states) and 12 healthy volunteers (HVs) were evaluated with videofluoroscopy (VFS) to assess the swallowing biomechanics and kinematics of the swallowing response at three different shear-viscosities (<50, 120, and 4000 mPa·s); (3) Results: Patients presented a mean age of 70.46 ± 10.03 years. Disease evolution was 5.09 ± 3.86 year and Hoehn-Yahr stage was 2.32 ± 0.81. For HVs, mean age was 40.20 ± 2.50 year. Penetrations were present in 37.50% of PD patients and were associated with delayed laryngeal vestibule closure (LVC = 293.33 ± 90.07 ms). In contrast, HVs presented a LVC = 164.00 ± 39.78 ms (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.