Evidence map›Paper›PMID 32899712›Full record

ReviewInternational journal of molecular sciences2020

Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies.

Emanuele Monda, Giuseppe Palmiero, Marta Rubino, Federica Verrillo, Federica Amodio, Francesco Di Fraia, Roberta Pacileo, Fabio Fimiani, Augusto Esposito, Annapaola Cirillo and 9 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Emanuele MondaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giuseppe PalmieroDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-5102-7460
Marta RubinoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Federica VerrilloDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Federica AmodioDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Francesco Di FraiaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Roberta PacileoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Fabio FimianiDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Augusto EspositoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Annapaola CirilloDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Adelaide FuscoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Elisabetta MoscarellaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giulia FrissoDipartimento di Medicina Molecolaree Biotecnologie Mediche, University of Naples "Federico II", 80138 Naples, Italy.ORCID 0000-0003-3487-7743
Maria Giovanna RussoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giuseppe PacileoDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Paolo CalabròDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-5018-830X
Olga ScudieroDipartimento di Medicina Molecolaree Biotecnologie Mediche, University of Naples "Federico II", 80138 Naples, Italy.ORCID 0000-0002-4916-4976
Martina CaiazzaDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giuseppe LimongelliDepartment of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITCeinge Biotecnologie Avanzate (Italy) · ITSt Bartholomew's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiomyopathies (CMPs) represent a diverse group of heart muscle diseases, grouped into specific morphological and functional phenotypes. CMPs are associated with mutations in sarcomeric and non-sarcomeric genes, with several suspected epigenetic and environmental mechanisms involved in determining penetrance and expressivity. The understanding of the underlying molecular mechanisms of myocardial diseases is fundamental to achieving a proper management and treatment of these disorders. Among these, inflammation seems to play an important role in the pathogenesis of CMPs. The aim of the present study is to review the current knowledge on the role of inflammation and the immune system activation in the pathogenesis of CMPs and to identify potential molecular targets for a tailored anti-inflammatory treatment.

Indexed as

AnimalsCardiomyopathiesHumansInflammationMutationPhenotypeSarcomerescardiomyopathiesinflammationpathogenesis

Identifiers

PMID32899712
PMCPMC7554875
OpenAlexW3083735130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.