ReviewBiomolecules2020
An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic.
Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.Frontiers in neurology · 2025Pooled it
- Intercellular Mitochondrial Transfer as Endogenous Neuroprotection: Mechanisms and Therapeutic Implications in Ischemic Stroke.Translational stroke research · 2026Review
- Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective.Archives of dermatological research · 2025Review
- Study on the relationship among typhoon, weather change and acute ischemic stroke in southern Zhejiang Province of China.BMC neurology · 2025Article
- Linc00205/Mir-495-3p/Tnfsf15 Axis is Implicated in the Treatment Effect of Hyperbaric Oxygen Therapy on Patients with Post-Stroke Cognitive Impairment.Noro psikiyatri arsivi · 2025Article
- Hyperbaric Oxygen Therapy in Children with Brain Injury: A Retrospective Case Series.International journal of medical sciences · 2025Article
- Endothelial Dysfunction and Cardiovascular Disease: Hyperbaric Oxygen Therapy as an Emerging Therapeutic Modality?Journal of cardiovascular development and disease · 2024Review
- Beyond Pharmacology: A Narrative Review of Alternative Therapies for Anxiety Disorders.Diseases (Basel, Switzerland) · 2024Review
- ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice.Scientific reports · 2024Article
- Article
- Polydopamine-modified black phosphorus nanosheet drug delivery system for the treatment of ischemic stroke.Regenerative biomaterials · 2024Article
- Research progress on high-concentration oxygen therapy after cerebral hemorrhage.Frontiers in neurology · 2024Review
- Recent Advances in Nanomaterials for Diagnosis, Treatments, and Neurorestoration in Ischemic Stroke.Frontiers in cellular neuroscience · 2022Review
- Hyperbaric oxygen influences chronic wound healing - a cellular level review.Physiological research · 2021Review
- Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.Biomolecules · 2021Review
- Mitochondria as the memory of preconditioning.Conditioning medicine · 2021Article
- Heat Shock Proteins in Oxidative Stress and Ischemia/Reperfusion Injury and Benefits from Physical Exercises: A Review to the Current Knowledge.Oxidative medicine and cellular longevity · 2021Review
- Hyperbaric Oxygen Therapy Attenuates Burn-Induced Denervated Muscle Atrophy.International journal of medical sciences · 2021Article
- Huperzine A combined with hyperbaric oxygen on the effect on cognitive function and serum hypoxia-inducible factor-1α Level in elderly patients with vascular dementia.American journal of translational research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.