Evidence map›Paper›PMID 32899591›Full record

ArticleInternational journal of molecular sciences2020

Understanding the Interaction Modes and Reactivity of Trimedoxime toward

Alexandre A de Castro, Daniel A Polisel, Bruna T L Pereira, Elaine F F da Cunha, Kamil Kuca, Eugenie Nepovimova, Teodorico C Ramalho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alexandre A de CastroDepartment of Chemistry, Federal University of Lavras, 37200-000 Lavras, Brazil.
Daniel A PoliselDepartment of Chemistry, Federal University of Lavras, 37200-000 Lavras, Brazil.
Bruna T L PereiraDepartment of Chemistry, Federal University of Lavras, 37200-000 Lavras, Brazil.
Elaine F F da CunhaDepartment of Chemistry, Federal University of Lavras, 37200-000 Lavras, Brazil.
Kamil KucaBiomedical Research Center, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Eugenie NepovimovaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03 Hradec Kralove, Czech Republic.
Teodorico C RamalhoDepartment of Chemistry, Federal University of Lavras, 37200-000 Lavras, Brazil.ORCID 0000-0002-7324-1353
Universidade Federal de Lavras · BRUniversity Hospital Hradec Králové · CZUniversity of Hradec Králové · CZ

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPqCoordenação de Aperfeiçoamento de Pessoal de Nível Superior/Ministério da Defesa CAPES/MDFederal University of Lavras UFLAFundação de Amparo ao Ensino e Pesquisa de Minas Gerais FAPEMIGUHK VT2019-2021
6 · The paper itself

Abstract

Organophosphorus (OP) compounds are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment. Thus, investigations with reactivators have been deeply developed in order to design new antidotes with better efficiency, as well as a greater spectrum of action in the acetylcholinesterase (AChE) reactivation process. With that in mind, in this work, we investigated the behavior of trimedoxime toward the

Indexed as

AcetylcholinesteraseAnimalsAntidotesCholinesterase InhibitorsCholinesterase ReactivatorsComputational BiologyHumansMiceNerve AgentsOrganophosphorus CompoundsOximesRatsTrimedoximeAcetylcholinesteraseAntidotesCholinesterase InhibitorsCholinesterase ReactivatorsNerve AgentsOrganophosphorus CompoundsOximesTrimedoximeacetylcholinesterasecomputational methodsmechanistic studiesnerve agentsreactivationtrimedoxime

Identifiers

PMID32899591
PMCPMC7554915
OpenAlexW3083157088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.