ArticleJournal of clinical medicine2020
Hematological Phenotype of COVID-19-Induced Coagulopathy: Far from Typical Sepsis-Induced Coagulopathy.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Time series differences in coagulopathy in mechanically ventilated COVID-19 and bacterial pneumonia patients: a nationwide observational study in Japan.Thrombosis journal · 2025Article
- Characteristics and Outcomes of New-Onset Cardiomyopathy in Hospitalized COVID-19 Patients.Journal of clinical medicine · 2025Article
- Daily combined measurement of platelet count and presepsin concentration can predict in-hospital death of patients with severe coronavirus disease 2019 (COVID-19).International journal of hematology · 2023Article
- Plasminogen activator inhibitor 1 is not a major causative factor for exacerbation in a mouse model of SARS-CoV-2 infection.Scientific reports · 2023Article
- Special Issue on "Disseminated Intravascular Coagulation: Current Understanding and Future Perspectives".Journal of clinical medicine · 2022Article
- Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital.Pathogens (Basel, Switzerland) · 2022Article
- Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex.Thrombosis research · 2022Article
- Major coagulation disorders and parameters in COVID-19 patients.European journal of medical research · 2022Review
- Novel prognostic determinants of COVID-19-related mortality: A pilot study on severely-ill patients in Russia.PloS one · 2022Article
- Review
- Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications.International journal of molecular sciences · 2021Review
- Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation.Critical care (London, England) · 2021Review
- Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity.JCI insight · 2021Article
- The Prothrombotic State Associated with SARS-CoV-2 Infection: Pathophysiological Aspects.Mediterranean journal of hematology and infectious diseases · 2021Review
- Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies.Frontiers in immunology · 2021Review
- Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality.Research and practice in thrombosis and haemostasis · 2021Article
- Hypercoagulopathy in Severe COVID-19: Implications for Acute Care.Thrombosis and haemostasis · 2020Review
- Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19.Frontiers in immunologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood coagulation disorders commonly occur with severe coronavirus disease 2019 (COVID-19). However, there is only limited evidence on differentiating the pattern of the hemostatic parameters from those of typical sepsis-induced coagulopathy (SIC).
methodsTo elucidate the specific pattern of coagulopathy induced by COVID-19 pneumonia, this retrospective, observational study targeted consecutive adult patients with COVID-19-induced acute respiratory distress syndrome (ARDS) and compared hemostatic biomarkers with non-COVID-19-induced septic ARDS. Multilevel mixed-effects regression analysis was performed and Kaplan-Meier failure curves were constructed.
resultsWe enrolled 24 patients with COVID-19-induced ARDS and 200 patients with non-COVID-19-induced ARDS. Platelet count, antithrombin activity, and prothrombin time in the COVID-19 group were almost within normal range and time series alterations of these markers were significantly milder than the non-COVID-19 group (
conclusionsThe hematological phenotype of COVID-19-induced coagulopathy is quite different from that in typical SIC characterized by systemic hypercoagulation and suppressed fibrinolysis. Instead, local thrombus formation might be promoted in severe COVID-19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.